Effects of Soluble Corn Fiber Alone or in Synbiotic Combination with Lactobacillus rhamnosus GG and the Pilus-Deficient Derivative GG-PB12 on Fecal Microbiota, Metabolism, and Markers of Immune Function: A Randomized, Double-Blind, Placebo-Controlled, Crossover Study in Healthy Elderly (Saimes Study)

Frontiers in Immunology
Adele CostabileGlenn R Gibson

Abstract

The aging process leads to a potential decline in immune function and adversely affects the gut microbiota. To date, many in vitro and in vivo studies focused on the application of synbiotics (prebiotics combined with probiotics) as a promising dietary approach to affect gut microbiota composition and improved functioning of the immune system. However, studies using synbiotic preparations often have the limitation that it remains unclear whether any effect observed is a result of the prebiotic or probiotic or a synergistic effect of the combined supplement. We investigated the effects of a probiotic Lactobacillus rhamnosus GG and pilus-deficient L. rhamnosus GG-PB12 combined with Promitor™ Soluble Corn Fiber (SCF, a candidate prebiotic) on fecal microbiota, metabolism, immunity, and blood lipids in healthy elderly persons. A prospective, double-blind, placebo controlled, randomized, single-centered, crossover study in 40 healthy elderly subjects (aged 60-80 years) was carried out. Volunteers were randomized to consume either probiotic and prebiotic as synbiotic, prebiotic or placebo (maltodextrin) during 3 weeks. Three-week washout periods separated all the treatments. We assessed effects upon blood lipids, glucose, cytokines, ...Continue Reading

References

Aug 5, 1999·Experimental Gerontology·R SolanaJ Peña
Mar 25, 2004·Journal of Leukocyte Biology·Timothy P PlackettElizabeth J Kovacs
Sep 29, 2004·JPEN. Journal of Parenteral and Enteral Nutrition·Daniel BunoutCarlos Muñoz
Mar 12, 2005·Science·Robert J KleinJosephine Hoh
Aug 2, 2005·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Michael de VreseJürgen Schrezenmeir
Oct 5, 2007·The New England Journal of Medicine·Kristin L NicholEelko Hak
Mar 18, 2008·Journal of Athletic Training·Minsoo KangJae-Hyeon Park
May 21, 2009·Analytical and Bioanalytical Chemistry·Harry Wichers
Jul 16, 2009·Environmental Microbiology·Julien TapMarion Leclerc
Jul 25, 2009·Transplant International : Official Journal of the European Society for Organ Transplantation·Daniela WeiskopfBeatrix Grubeck-Loebenstein
Aug 28, 2009·Nestlé Nutrition Workshop Series. Paediatric Programme·Seppo SalminenMiguel Gueimonde
Jan 15, 2010·International Journal of Food Microbiology·Patricia LópezAna Suárez
Jan 22, 2010·Annals of Nutrition & Metabolism·Maria L StewartJoanne L Slavin
Jan 27, 2010·The British Journal of Nutrition·Haleh Sadrzadeh-YeganehMaryam Chamary
Feb 2, 2010·Journal of the American College of Cardiology·Raffaele De CaterinaRoberto Marchioli
Jun 17, 2010·The Proceedings of the Nutrition Society·Ibrahim ElmadfaAlexa L Meyer
Jan 26, 2011·Human Immunology·Aline Almeida-OliveiraHilda Rachel Diamond
Mar 18, 2011·International Journal of Sport Nutrition and Exercise Metabolism·Michael GleesonPedro Tauler
Jul 9, 2011·The British Journal of Nutrition·Brittany M Vester BolerGeorge C Fahey
Aug 11, 2011·PloS One·Francesc Peris-BondiaGiuseppe D'Auria
Nov 8, 2011·The British Journal of Nutrition·Honglin DongParveen Yaqoob
Jan 1, 2010·Annual Review of Food Science and Technology·Noriko NakamuraH Rex Gaskins
Jan 19, 2012·Nutrients·Asa Hakansson, Goran Molin
Dec 12, 2012·Frontiers in Physiology·Franck CarboneroH Rex Gaskins
Jan 1, 2014·Mechanisms of Ageing and Development·Marco CandelaWillem M De Vos
Dec 19, 2014·Microbiome·Morgan Gi LangilleRobert G Beiko

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Citations

Jul 28, 2018·Expert Review of Gastroenterology & Hepatology·Bobbi LaingLynnette R Ferguson
May 15, 2019·Microorganisms·Franca RossiGiampaolo Colavita
May 1, 2020·Bioscience Reports·Bo ZhangChunsheng Li
May 28, 2019·Frontiers in Immunology·Alessandro PoggiMaria Raffaella Zocchi
Nov 30, 2018·Current Opinion in Clinical Nutrition and Metabolic Care·Andrea TicinesiAntonio Nouvenne
Oct 1, 2020·Immunology and Cell Biology·Radha Pujari, Gautam Banerjee
Mar 23, 2021·Critical Reviews in Biotechnology·Ayushi MishraSachin Mandavgane
Sep 27, 2020·Experimental Gerontology·Vasile Coman, Dan Cristian Vodnar
May 8, 2021·Frontiers in Veterinary Science·Patrick von SchaumburgMaria R C de Godoy
Nov 26, 2020·Food Research International·Yuan SongJun-Qing Huang

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Methods Mentioned

BETA
flow cytometry
PCR
amplicon sequencing

Clinical Trials Mentioned

NCT03168503

Software Mentioned

R package
Hedwig Harvard
SPSS
package vegan
MxPro qPCR
[UNK] CBA
Food Processor SQL Nutrition Analysis and Fitness
Excel
R
FlowJo

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