PMID: 8941868Oct 1, 1996Paper

Effects of soluble sodium alginate on cholesterol excretion and glucose tolerance in rats

Journal of Ethnopharmacology
Y KimuraH Okuda

Abstract

We studied the effects of a natural sodium alginate (isolated from Laminaria angustata Kjellman var. longissima Miyabe, Phaeophyceae) (average molecular weight: 2700 kDa; AG-270) and three water-soluble low-molecular weight sodium alginates (average molecular weights, 10, 50 and 100 kDa; AG-1, AG 5, and AG-10, respectively) on cholesterol excretion and glucose tolerance in rats. AG-270, AG-5 and AG-10 enhanced cholesterol excretion into faeces. AG-270 and AG-10 inhibited blood glucose and insulin levels from rising 30 min after glucose administration. AG-5 inhibited the blood glucose level from rising 30 and 60 min after glucose administration, without affecting blood insulin levels. AG-1 had no effect on cholesterol excretion or glucose tolerance. These findings suggest that the effects of the natural sodium alginate and AG-5 and AG-10 on cholesterol excretion and glucose tolerance may be due to the inhibition of cholesterol and glucose absorption from the small intestine by the gelling of the free alginic acid converted in the stomach. These experimental results indicate that the low-molecular weight sodium alginates, AG-5 and AG-10, should be useful as dietary fibers for the prevention of obesity, hypercholesterolemia, and d...Continue Reading

References

Apr 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·B E Peerce, E M Wright
May 1, 1981·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·K DaigoT Miyazato
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Citations

May 2, 2008·Naunyn-Schmiedeberg's Archives of Pharmacology·Shinichi WatanabeHiroaki Araki
Apr 12, 2002·Veterinary Immunology and Immunopathology·Scott PeddieChristopher J Secombes
Sep 27, 2005·Critical Reviews in Food Science and Nutrition·I A BrownleeE Onsøyen
Oct 8, 2009·Bioscience, Biotechnology, and Biochemistry·Mitsuyoshi MiyataKazunaga Yazawa
Feb 2, 2016·Marine Drugs·Maria Filomena de Jesus RaposoRui Manuel Santos Costa de Morais
Nov 9, 2011·The Journal of Pharmacy and Pharmacology·Tin Wui Wong
Nov 14, 2012·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·M Georg JensenA Astrup
Jun 11, 2014·Critical Reviews in Food Science and Nutrition·D El KhouryG H Anderson
Dec 12, 2012·Carbohydrate Polymers·Kézia O A L LinsLetícia V Costa-Lotufo
Dec 6, 2016·Marine Drugs·Chiara Lauritano, Adrianna Ianora
Feb 17, 2017·Journal of Nutritional Science and Vitaminology·Kazuhiro KuboMorio Saito
May 10, 2017·Bioscience, Biotechnology, and Biochemistry·Mikinori UenoTatsuya Oda
Mar 22, 2020·Marine Drugs·Ana DobrinčićVerica Dragović-Uzelac
Mar 4, 2020·Marine Drugs·Maochen XingShuliang Song
Jan 28, 2021·Foods·Rebeca AndréMaria Luísa Serralheiro
Dec 31, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Biswajita PradhanMrutyunjay Jena
Sep 12, 2020·Current Pharmaceutical Design·Lavanya RayapuLokanatha Valluru

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