Effects of somatosensory stimulation on corticomotor excitability in patients with unilateral cerebellar infarcts and healthy subjects - preliminary results

Cerebellum & Ataxias
Suzete Nascimento Farias da Guarda, Adriana Bastos Conforto

Abstract

In healthy humans, somatosensory stimulation in the form of 2 h-repetitive peripheral afferent nerve stimulation (SS) increases excitability of the contralateral motor cortex. In this preliminary study, we explored effects of SS on excitability to transcranial magnetic stimulation (TMS) in patients with unilateral cerebellar infarcts and age-matched controls. Ten patients with infarcts in one cerebellar hemisphere and six age-matched controls participated in the study. Each subject participated in one session of active, and one session of sham SS delivered to the median nerve ipsilateral to the cerebellar infarct in patients, and to the homologous nerve in controls. Before and after each session, the following TMS measures were performed: resting motor threshold (rMT), motor evoked potentials (MEPs), short-interval intracortical inhibition (SICI) and short-interval intracortical facilitation (SICF). Amplitudes of motor evoked potentials were normalized to amplitudes of supramaximal M responses (MEP/M ratios). In the control group, there was a significant increase in rMT, and a significant increase in MEP/M ratios after active, but not after sham SS. There were no significant differences in rMT or MEP/M ratios in the group of pa...Continue Reading

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