PMID: 8592117Feb 1, 1996Paper

Effects of somatostatin on intracellular calcium concentration in PC12 cells

Journal of Neurochemistry
G TrainaP Bagnoli

Abstract

Somatostatin (SS) is a neuropeptide that is distributed in various regions of the CNS, where it may act as a neurotransmitter or neuromodulator. SS produces multiple effects in the CNS through interactions with membrane receptors. In particular, SS inhibits various secretory responses in different cell types. In the present study, we have investigated the effects of exogenous application of SS on the intracellular free Ca2+ concentration ([Ca2+]i) in PC12 cells, a rat pheochromocytoma cell line. SS did reduce the magnitude of the secondary, maintained Ca2+ influx brought about by K+ depolarization. Similar effects were obtained with the application of SS analogues, such as D-Trp8-SS, D-Trp8-D-Cys14-SS, CGP-23996, and SMS-201995. In addition, treatment with cyclo-SS, a SS antagonist, did not alter [Ca2+]i. Experiments with selective blockers of different voltage-dependent Ca2+ channels, such as methoxyverapamil (D600) and omega-conotoxin GVIA, demonstrated that the effects of SS on [Ca2+]i were mediated by voltage-dependent Ca2+ channels of the L type. Control experiments with a membrane potential indicator, i.e., the fluorescent dye bisoxonol, excluded that SS influenced the level of the membrane potential. SS effects on PC12 c...Continue Reading

Citations

Jan 1, 1997·British Journal of Pharmacology·J A KoenigP P Humphrey
Mar 11, 2000·British Journal of Pharmacology·C PetrucciP Bagnoli
Apr 19, 2007·Apoptosis : an International Journal on Programmed Cell Death·Davide CerviaFernando Dini
Dec 5, 1998·Brain Research. Developmental Brain Research·G TrainaP Bagnoli
Aug 28, 2007·Pharmacology & Therapeutics·Davide Cervia, Paola Bagnoli

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