PMID: 6167804Jul 1, 1981Paper

Effects of some catecholamines on the cat cardiovascular system: interactions with adrenoceptor antagonists

Journal of Cardiovascular Pharmacology
G A McPhersonC Raper

Abstract

The effects of intravenous infusions of norepinephrine, epinephrine, isoproterenol, N-t-butylnorepinephrine, oxymethyleneisoproterenol, and RO363 on heart rate, mean arterial blood pressure, cardiac output, total peripheral resistance, and stroke volume were evaluated in chloralose-anaesthetized cats before and after phentolamine, propranolol, atenolol, and butoxamine. Pressor responses to both norepinephrine and epinephrine largely resulted from alpha-receptor-mediated increases in total peripheral resistance. Vasomotor reversal was noted with both drugs in the presence of alpha-receptor blockade. Dilator responses to norepinephrine were abolished by the beta 1-receptor selective antagonist atenolol, as were those to the beta 1-receptor selective agonists oxymethyleneisoproterenol and RO363. Dilator responses to epinephrine were abolished by the beta 2-receptor selective antagonist butoxamine, as were those to N-t-butylnorepinephrine (beta 2-selective) and isoproterenol (nonselective). These results indicate that in addition to beta 2-receptors, beta 1-receptors subserving vasodilatation occur in the cat vasculature. Atenolol displayed agonist-dependent inhibition of the cardiac responses. Responses to noradrenaline, RO363, an...Continue Reading

Citations

Jul 1, 1983·Naunyn-Schmiedeberg's Archives of Pharmacology·C MaccarroneC Raper
Jul 1, 1983·Clinical and Experimental Pharmacology & Physiology·C MaccarroneC Raper
Sep 5, 2006·American Journal of Veterinary Research·Peter J PascoeBruno H Pypendop
Dec 11, 2013·The Veterinary Journal·Kuan Hua KhorPaul C Mills

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