Effects of some neurosteroids injected into some brain areas of WAG/Rij rats, an animal model of generalized absence epilepsy

Neuropharmacology
Rita CitraroGiovambattista De Sarro

Abstract

Neurosteroids are synthesized in the brain and have been demonstrated to modulate various cerebral functions. Allopregnanolone (3alpha-hydroxy-5alpha-pregnan-20-one), a naturally occurring neurosteroid, and ganaxolone (3alpha-hydroxy-3beta-methyl-5alpha-pregnan-20-one), a synthetic derivative, are two neurosteroids acting as positive allosteric modulators of the GABA(A) receptor complex acting on a specific steroid recognition site. Both agents antagonize generalized tonic-clonic seizures in various animal models of epilepsy. Pregnenolone sulphate (3beta-hydroxy-5alpha-pregnen-20-one 3-sulphate; PS) is a negative allosteric modulator of GABA(A) receptors and a positive modulator of the NMDA receptors. We have evaluated the effects of such compounds in a genetic animal model of absence epilepsy, the WAG/Rij rat. Animals were chronically implanted with five frontoparietal cortical electrodes for electrocorticogram (EEG) recordings and bilateral guide cannulae into specific brain areas of the cortico-thalamic circuit in order to evaluate the effects of these compounds on the number and duration of epileptic spike-wave discharges (SWDs). The focal and bilateral microinjection of the two GABA(A) positive modulators into some thalami...Continue Reading

References

Jul 1, 1992·Epilepsy Research·A M CoenenE L van Luijtelaar
May 1, 1991·Brain Research. Molecular Brain Research·W WisdenS P Hunt
Jan 1, 1991·Trends in Neurosciences·V Crunelli, N Leresche
Jan 1, 1990·Life Sciences·B W PeetersA M Coenen
Jan 1, 1990·Neuroscience and Biobehavioral Reviews·D BelelliK W Gee
Nov 20, 1990·The Journal of Steroid Biochemistry and Molecular Biology·E E Baulieu, P Robel
Jan 1, 1989·Pharmacology, Biochemistry, and Behavior·A M Coenen, E L van Luijtelaar
Jul 18, 1989·European Journal of Pharmacology·D BelelliK W Gee
Aug 1, 1988·British Journal of Pharmacology·J A PetersA J Turner
Oct 1, 1986·Physiology & Behavior·J P Kroon, A L Riley
Apr 29, 1987·European Journal of Pharmacology·K W GeeB S McEwen
Jan 1, 1984·Annals of Neurology·J L Noebels
Sep 1, 1995·Trends in Pharmacological Sciences·J J LambertJ A Peters
Jan 1, 1995·Epilepsia·E L van LuijtelaarA M Coenen
Feb 1, 1995·Italian Journal of Neurological Sciences·C Marescaux, M Vergnes
Jan 16, 1995·European Journal of Pharmacology·D B Goodnough, J E Hawkinson
Apr 25, 1995·Proceedings of the National Academy of Sciences of the United States of America·F P MonnetE E Baulieu
Feb 1, 1995·Annals of Neurology·O C Snead
May 1, 1994·The Journal of Clinical Endocrinology and Metabolism·S H Mellon
Dec 1, 1995·Progress in Neurobiology·H F Bradford
Sep 1, 1996·Epilepsy Research·C KoernerM Vergnes
Oct 6, 1997·Science·U KimD A McCormick
Feb 7, 1998·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·B BudziszewskaW Lasoń
May 14, 1998·Epilepsia·A G HerzogB J Ransil
May 29, 1998·Progress in Neurobiology·L DanoberC Marescaux
Sep 30, 1998·The European Journal of Neuroscience·T SeidenbecherH C Pape

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Citations

May 23, 2014·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Giuseppina Mattace RasoRosaria Meli
Aug 19, 2014·Neurobiology of Disease·Gilles van LuijtelaarMartin J Gallagher
Feb 18, 2010·Current Opinion in Neurology·Giuseppe BiaginiMassimo Avoli
Dec 23, 2015·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Gaetano Zaccara, Dieter Schmidt
Feb 7, 2007·Neuroscience Letters·Elena A Tolmacheva, Gilles van Luijtelaar
Jul 16, 2008·Journal of Neurochemistry·Maria Giuseppina PisuMariangela Serra
Apr 5, 2015·Expert Opinion on Therapeutic Targets·Antonio LeoEmilio Russo
Nov 26, 2010·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Gilles van LuijtelaarAlexei Koronovskii
Oct 18, 2014·Journal of Molecular Neuroscience : MN·Gönül GürolAyşe Karson
Oct 30, 2016·Neuroscience and Biobehavioral Reviews·Emilio RussoGiovambattista De Sarro
Jun 17, 2011·Clinical EEG and Neuroscience·Gilles van LuijtelaarAnnika Littjohann
Nov 9, 2018·Expert Opinion on Investigational Drugs·Marco GrecoMaria Laura Iezzi
Oct 30, 2020·Frontiers in Endocrinology·Barbara MiziakStanisław J Czuczwar
Mar 17, 2021·Expert Review of Neurotherapeutics·Simona LattanziPasquale Striano

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