PMID: 6540226Jul 1, 1984Paper

Effects of sorbic acid and its salts on chromosome aberrations, sister chromatid exchanges and gene mutations in cultured Chinese hamster cells

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
M M HasegawaN Inui

Abstract

The ability of sorbic acid and its potassium and sodium salts to induce chromosome aberrations, sister chromatid exchanges (SCE) and gene mutations in cultured Chinese hamster V79 cells was examined. Sodium sorbate caused significant induction of chromosome aberrations and SCE, and also induced 6-thioguanine-resistant mutations in a dose-dependent manner. The clastogenic potency of sodium sorbate was found to be less than one hundredth of that of the potent clastogen N-methyl-N'-nitro-N-nitrosoguanidine. The induction of SCE by sodium sorbate was twice the control level, whereas that by methyl methanesulphonate, a potent inducer of SCE, was 14 times the control level. The mutagenic potency of sodium sorbate was less than one-tenth that of ethyl methanesulphonate, a potent inducer of mutation, when compared at an equitoxic level. Sorbic acid and its potassium salt induced chromosome aberrations, but only at the highest doses tested. These compounds also induced 1.2 times the control level of SCE, but neither compound induced 6-thioguanine-resistant mutations. The cytogenetic activity of sodium sorbate was concluded not to be due to the effect of osmotic pressure or an impurity. These results indicate that sodium sorbate is a gen...Continue Reading

References

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Citations

Mar 1, 2012·Cytotechnology·Sevcan MamurHüseyin Aksoy
Oct 1, 1992·Mutation Research·F E WürglerP Maier
Jun 1, 1990·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R MünznerH W Renner
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Jan 1, 1992·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R JungE Lück
Aug 1, 1992·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·D Schiffmann, J Schlatter
Aug 15, 2002·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·K KitanoH Yamaguchi
Sep 1, 1992·Food Additives and Contaminants·E Quattrucci, V Masci
May 10, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·P MpountoukasT Lialiaris
Aug 15, 2006·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Christiana WinklerDietmar Fuchs
Mar 11, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Sifa Türkoğlu
Jan 27, 2017·Annual Review of Food Science and Technology·Marilyn C Erickson, Michael P Doyle
Jan 1, 1987·Environmental Mutagenesis·A Sharma, G Talukder
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