Effects of sound level on fMRI activation in human brainstem, thalamic and cortical centers.

Hearing Research
Irina S Sigalovsky, Jennifer R Melcher

Abstract

The dependence of fMRI activation on sound level was examined throughout the auditory pathway of normal human listeners using continuous broadband noise, a stimulus widely used in neuroscientific investigations of auditory processing, but largely neglected in neuro-imaging. Several specialized techniques were combined here for the first time to enhance detection of brainstem activation, mitigate scanner noise, and recover temporal resolution lost by the mitigation technique. The main finding was increased activation with increasing level in cochlear nucleus, superior olive, inferior colliculus, medial geniculate body and auditory cortical areas. We suggest that these increases reflect monotonically increasing activity in a preponderance of individual auditory neurons responsive to broadband noise. While the time-course of activation changed with level, the change was subtle and only significant in a part of the cortex. To our knowledge, these are the first fMRI data showing the effects of sound level in subcortical centers or for a non-tonal, non-speech stimulus at any stage of the pathway. The present results add to the body of parametric data in normal human listeners and are fundamental to the design of any fMRI experiment e...Continue Reading

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Citations

Feb 23, 2012·Journal of the Association for Research in Otolaryngology : JARO·Markus Röhl, Stefan Uppenkamp
Jan 8, 2013·Hearing Research·Yongmin Chang, Sang-Heun Lee
Jun 16, 2012·Proceedings of the National Academy of Sciences of the United States of America·Norbert KopčoJyrki Ahveninen
Aug 15, 2008·Journal of Neurophysiology·Dongyang ZhangMarcus E Raichle
Apr 7, 2010·Neuropsychologia·René WesterhausenKenneth Hugdahl
Aug 25, 2009·Hearing Research·Jennifer R MelcherBarbara Norris
Jan 7, 2009·Neuropsychologia·Patrick C M WongSumitrajit Dhar
Jul 8, 2015·NeuroImage·Nicole Angenstein, André Brechmann
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Oct 11, 2011·NeuroImage·Ian M DevonshirePaul G Overton
Jan 27, 2007·NeuroImage·Dave R M LangersWalter H Backes
Jan 17, 2012·NeuroImage·Thomas M Talavage, Deborah A Hall
Nov 8, 2016·Neurobiology of Aging·Catharina ZichCornelia Kranczioch
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Oct 17, 2008·Journal of Neurophysiology·Teemu RinneMikko Sams
Jul 27, 2017·Journal of Morphology·Agustin J Elias-CostaJulián Faivovich
Apr 11, 2018·Journal of the Association for Research in Otolaryngology : JARO·Stefan WederColette McKay

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