Effects of SOX15 on the colorectal cancer cells via downregulation of the Wnt/β-catenin signaling pathway

Future Oncology
Shuang WangZheng Jiang

Abstract

To detect the function and mechanism of SOX15 in colorectal cancer. The expression of SOX15 in colorectal cancer (CRC) cells and tissues was detected by real-time PCR, quantitative real-time PCR and immunohistochemistry. The overexpression of SOX15 in cells was tested by western blot, CCK-8, FACS analysis, transwell and clone assay. Moreover, SOX15 regulated Wnt pathway investigated by western blot. We found that SOX15 has a low-expression in CRC cells and tissues. Overexpression of SOX15 can inhibit the proliferation, migration and invasion of cells and induce cells apoptosis. Furthermore, SOX15 could be the inhibitor of Wnt/β-catenin pathway in CRC. SOX15 can be a tumor suppressor in CRC by suppressing the Wnt/β-catenin signaling pathway.

References

Mar 27, 2001·Nature Reviews. Genetics·K D Robertson, A P Wolffe
Apr 6, 2002·Biological Chemistry·Helen BrantjesHans Clevers
Jul 8, 2008·Acta Biochimica Et Biophysica Sinica·Yadi Wu, Binhua P Zhou
Mar 6, 2009·Nature Reviews. Cancer·Kornelia Polyak, Robert A Weinberg
May 7, 2010·Aging·Per Hydbring, Lars-Gunnar Larsson
Aug 6, 2013·Cancer Research·Longtao WuJindan Yu
Mar 19, 2014·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Jul 9, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Dangjun ZhouRong Liu
Dec 17, 2014·Journal of Experimental & Clinical Cancer Research : CR·Lisha QiXiulan Zhao
Apr 29, 2015·Journal of Cellular Biochemistry·Alexander W FenderGeorge Sigounas
Jun 5, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ning YangXuejun Jiang
Oct 31, 2015·Cellular and Molecular Gastroenterology and Hepatology·Rita SulahianRamesh A Shivdasani
Nov 20, 2015·Cancer Research·Mathew C CasimiroRichard G Pestell
Jan 15, 2016·The Journal of Biological Chemistry·Shuchen GuXin-Hua Feng
Jan 26, 2016·CA: a Cancer Journal for Clinicians·Wanqing ChenJie He
Nov 24, 2017·Cancer Treatment Reviews·Nithya Krishnamurthy, Razelle Kurzrock

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
flow cytometry
protein assay

Software Mentioned

SPSS
- QUEST
CELL

Related Concepts

Related Feeds

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Adherens Junctions

An adherens junction is defined as a cell junction whose cytoplasmic face is linked to the actin cytoskeleton. They can appear as bands encircling the cell (zonula adherens) or as spots of attachment to the extracellular matrix (adhesion plaques). Adherens junctions uniquely disassemble in uterine epithelial cells to allow the blastocyst to penetrate between epithelial cells. Discover the latest research on adherens junctions here.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Cadherins and Catenins

Cadherins (named for "calcium-dependent adhesion") are a type of cell adhesion molecule (CAM) that is important in the formation of adherens junctions to bind cells with each other. Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells: alpha-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. Discover the latest research on cadherins and catenins here.