Effects of soy on the mammary glands of premenopausal female monkeys

Fertility and Sterility
Charles E WoodJ Mark Cline

Abstract

To evaluate the interactive effects of dietary soy and menstrual cycle phase on breast proliferation, apoptosis, and sex steroid receptor expression in premenopausal female cynomolgus monkeys. Animals were randomized to receive diets with either casein lactalbumin or soy as the protein source for 12 months. Paired follicular and luteal mammary gland biopsies were taken before and after treatment and evaluated for epithelial proliferation and area, apoptosis, and sex steroid receptor expression. Academic research environment. Fifty-two adult female cynomolgus monkeys (Macaca fascicularis). Soy protein with the human equivalent of 129 mg/d of isoflavones. Breast proliferation and epithelial area. Follicular and luteal assessments were taken on cycle day (+/- SE) 5.3 +/- 0.1 and 22.0 +/- 0.1, respectively. Serum E2, serum P, breast proliferation, and vaginal maturation were significantly higher in the luteal vs. follicular phase. Soy treatment resulted in significantly higher serum isoflavone concentrations compared with the casein lactalbumin group but did not significantly affect breast proliferation, epithelial area, apoptosis, or progesterone receptor expression; uterine size; or vaginal maturation in either the follicular or ...Continue Reading

Citations

Aug 3, 2012·Nutrition Research Reviews·Dorothy TeegardenSophie A Lelièvre
Oct 20, 2009·Nutrition and Cancer·Gertraud MaskarinecJ Mark Cline
May 11, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J H ChenC E McLaren
Oct 29, 2010·The Journal of Nutrition·Leena Hilakivi-ClarkeWilliam Helferich
Jul 23, 2008·American Journal of Primatology·Melissa Emery ThompsonAnne E Pusey
Sep 26, 2006·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Karl K RozmanDavid Umbach
Oct 18, 2007·Current Opinion in Endocrinology, Diabetes, and Obesity

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