PMID: 574769Nov 1, 1979Paper

Effects of soy protein and saponins on serum, tissue and feces steroids in rat

Atherosclerosis
C SautierD Lemonnier

Abstract

Four groups of rats were fed, for 45 days, one of the following semipurified diets containing sucrose 55% (w/w) and (a) casein 25%, (b) casein 24%, saponins (from Saponaria officinalis) 1%, (c) isolated soy protein 25%, (d) soy protein 24%, saponins 1%. The soy protein diet, compared to the casein one, produced an increase in the fecal excretion of neutral sterols on the 29th and 42nd days, without any modification in the liver, aorta and serum cholesterol concentrations. The effect of soy protein cannot be attributed to its saponin content but other substances associated to soy protein may interfere. With the casein diet, added saponins increased the fecal excretion of neutral sterols and bile acids and decreased liver and aorta cholesterol levels. Serum cholesterol was found unchanged. The effects of saponins were suppressed or greatly reduced with the soy protein diet. These results could be explained by binding of the sterols in insoluble forms.

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Citations

Feb 15, 1988·Klinische Wochenschrift·C A Barth, M Pfeuffer
May 13, 1982·Biochimica Et Biophysica Acta·D J McNamaraK D Edwards
Aug 1, 1980·Atherosclerosis·C PathiranaT G Taylor
Feb 1, 1983·Atherosclerosis·C E WestC J Woodward
Jun 18, 1998·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·S M Wright, A M Salter
Jan 1, 1994·Critical Reviews in Food Science and Nutrition·I E Liener
May 1, 2004·Journal of Medicinal Food·John ShiYueming Jiang
Dec 1, 1981·Experimental and Molecular Pathology·D N KimW A Thomas
Sep 1, 1984·Atherosclerosis·T G Redgrave
Sep 1, 1983·Atherosclerosis·D G Oakenfull, D L Topping
Mar 1, 1981·The British Journal of Nutrition·Y NagataM Sugano
Jun 3, 2021·International Journal of Molecular Sciences·Il-Sup KimCheorl-Ho Kim

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