Effects of soy protein hydrolysate on blood pressure and angiotensin-converting enzyme activity in rats with chronic renal failure

Hypertension Research : Official Journal of the Japanese Society of Hypertension
Hsin-Yi YangLe-Shin Chang

Abstract

We investigated the effects of soy protein and soy protein hydrolysate on blood pressure control, angiotensin-converting enzyme (ACE) activity, and renal function in a rat chronic renal failure model. Rats that had undergone a 5/6 nephrectomy were separated into three groups and fed different experimental diets for 14 weeks. At the end of the study, rats that fed a diet containing soy protein as the protein source had better blood pressure control and renal function, as well as lower circulating ACE activity and renal tumor-necrosis factor-alpha (TNF-alpha) concentration than rats fed a casein protein diet. Soy protein hydrolysate was shown to be as effective as soy protein in preventing the elevation of blood pressure, the progression of renal failure, and decreases in kidney TNF-alpha level, plasma ACE activity, and insulin concentration. In conclusion, the beneficial effects of consuming soy protein on blood pressure and renal function may be mediated mostly by its pepsin-digested hydrolysate through its ACE inhibitory activity.

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Citations

Feb 5, 2010·Canadian Journal of Physiology and Pharmacology·Nallasamy PalanisamyCarani Venkataraman Anuradha
May 7, 2016·World Journal of Nephrology·Nancy J McGrawAlan R Parrish
Aug 9, 2013·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Jung Hyun KwakJong Ho Lee
Oct 6, 2010·Experimental Biology and Medicine·Malcolm R OgbornHarold M Aukema
Jan 12, 2021·Frontiers in Medicine·Adamasco CupistiGiorgina B Piccoli
May 9, 2009·Journal of Agricultural and Food Chemistry·Zhen-Yu ChenYu Huang

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