Effects of soy protein isolate feeding on severe kidney damage in DOCA salt-treated obese Zucker rats

Journal of Agricultural and Food Chemistry
Masashi AsanomaYasuo Watanabe

Abstract

This study assessed the effects of soy protein isolate (SPI) on severe kidney damage in deoxycorticosterone acetate (DOCA) salt-treated obese Zucker rats. These rats underwent heminephrectomy and were fed either casein or SPI diet for 12 weeks. From weeks 8 to 10 of the experiment, kidney damage was induced by biweekly injection of 25 mg/kg DOCA and administration of 0.5% NaCl (w/v) ad libitum. Urinary protein and N-acetyl-β-d-glucosaminidase excretions of SPI rats were much lower than those of casein rats at weeks 1 (p < 0.01) and 2 (p < 0.05) after DOCA treatment. Abnormal mineral excretions induced by DOCA treatment in casein rats were hardly detected in SPI rats. Severe atrophy of tubular epithelium and some flattened/detached renal tubules were also observed in casein rats, but not in SPI rats. These results indicate that consecutive treatment of SPI protects against renal dysfunction, particularly tubulointerstitial nephritis, in DOCA salt-treated obese Zucker rats.

References

Aug 3, 1995·The New England Journal of Medicine·J W AndersonM E Cook-Newell
Jan 1, 1995·Proceedings of the Society for Experimental Biology and Medicine·H WeiY Wang
Nov 13, 1998·The New England Journal of Medicine·G Remuzzi, T Bertani
Jan 12, 2002·Kidney International·David A MaddoxEdward T Zawada
Sep 19, 2002·Journal of Agricultural and Food Chemistry·Kensuke FukuiTadahisa Shimoda
Mar 28, 2003·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·A NagasawaY Matsuzawa
Nov 19, 2003·Biochemical and Biophysical Research Communications·Azumi NagasawaYuji Matsuzawa
Apr 17, 2004·Kidney International·Kunitoshi IsekiShuichi Takishita
Aug 26, 2004·American Journal of Physiology. Renal Physiology·Joyce TrujilloNorma A Bobadilla
May 12, 2005·Journal of Agricultural and Food Chemistry·Nobuhiko TachibanaKiyoharu Takamatsu
Jul 5, 2005·Journal of Lipid Research·Armando R TovarNimbe Torres
Aug 19, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Ihab M Wahba, Robert H Mak
Sep 26, 2008·American Journal of Physiology. Renal Physiology·Joyce TrujilloNorma A Bobadilla

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Citations

May 7, 2016·World Journal of Nephrology·Nancy J McGrawAlan R Parrish

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