Effects of spinal cord stimulation on the flexor reflex and involvement of supraspinal mechanisms: an experimental study in mononeuropathic rats

Journal of Neurosurgery
B RenBjörn A Meyerson

Abstract

The physiological mechanisms responsible for pain relief caused by spinal cord stimulation (SCS) are essentially unknown and recent experimental data are sparse. In the present study the authors explored the possible involvement of supraspinal mechanisms in the effects of SCS applied in rats with experimental mononeuropathy produced by sciatic nerve ligation according to the method of Bennett and Xie or that of Seltzer, et al. Confirming results of a previous study undertaken by the authors, the thresholds of the early component of the flexor reflex (latency 8-12 msec), which is mediated by A fibers, were significantly lower in the nerve-ligated than in the intact leg. In halothane-anesthetized animals the spinal cord was exposed and SCS was applied with parameters similar to those used in clinical SCS. Ten minutes of SCS produced a significant elevation of the lowered threshold of the early flexor component only in the nerve-ligated leg, and this augmentatory effect of SCS persisted for 30 to 40 minutes after cessation of the stimulation. The threshold elevation amounted to between 50% and 80% of the prestimulatory value and it was related to the intensity of SCS. The threshold of the late, C-fiber-mediated component of the fl...Continue Reading

References

Mar 1, 1975·Journal of Neurosurgery·H BantliP Thienprasit
Jan 1, 1991·Acta neurochirurgica. Supplementum·J Siegfried
Nov 1, 1989·Pain·L García-LarreaF Mauguière
Sep 1, 1986·Experimental Neurology·J A McMillanH S Griffith
Aug 1, 1974·Journal of Neurosurgery·S J LarsonT Swiontek
Nov 19, 1965·Science·R Melzack, P D Wall
Jan 1, 1980·Applied Neurophysiology·P L Gildenberg, K S Murthy
Jan 1, 1994·Stereotactic and Functional Neurosurgery·B A MeyersonB Ren
Feb 15, 1990·Physical Review. a·H K Leung

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Citations

Mar 9, 2012·Current Pain and Headache Reports·Yun Guan
May 1, 1997·Journal of Pain and Symptom Management·J DevulderG Rolly
Apr 23, 2004·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Y E Mironer, J J Somerville
Apr 25, 2007·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Hubert PolácekAndrej Stancák
Aug 2, 2011·Pain Practice : the Official Journal of World Institute of Pain·Patricia NelsonPhilip S Sizer
Jul 1, 1999·Neuromodulation : Journal of the International Neuromodulation Society·B Linderoth, R D Foreman
Jul 13, 2012·The Korean Journal of Pain·Young Hoon Jeon
May 20, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Harry L JuneGregg E Homanics
Sep 10, 2002·Acupuncture in Medicine : Journal of the British Medical Acupuncture Society·Christer Carlsson
Nov 19, 2002·Spine·John C Oakley, Joshua P Prager

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