PMID: 6112048May 11, 1981Paper

Effects of spinal cord transection on synapse numbers and biochemical maturation in rat lumbar sympathetic ganglia

Brain Research
J M LawrenceI B Black

Abstract

The effects of interruption of descending central pathways on the morphological and biochemical ontogeny of peripheral sympathetic ganglia were examined in the sixth lumbar (L6) sympathetic rat ganglia. Previous studies defined the normal maturation of presynaptic choline acetyltransferase (CAT) activity, postsynaptic tyrosine hydroxylase (T-OH) activity, and total protein in the L6 ganglion. In the present investigations ganglion synapse numbers and adrenergic neuron numbers were examined in transected and sham-operated littermate controls 6 weeks after surgery at 10 days of age and correlative biochemical studies were performed. Spinal transection resulted in a reduction in synapse number on ganglion cell bodies (53.5% reduction) and neuronal processes (55.8% reduction). This abnormality in synapse number was associated with a reduction of CAT activity to 56% of control. Although T-OH activity also failed to develop normally and was 25% of control, there was no associated alteration in adrenergic neuron number. These studies suggest that descending central pathways regulate the maturation of presynaptic cholinergic terminals (and hence synapse number) in sympathetic ganglion and that CAT activity serves as an accurate marker ...Continue Reading

References

Oct 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·I B BlackR W Hamill
Jun 28, 1956·The Journal of Physiology·C O HEBB, G M WAITES
Jan 23, 1957·The Journal of Physiology·J G MURRAY, J W THOMPSON
Apr 1, 1961·Experimental Neurology·L GUTH, C J BAILEY
Nov 1, 1978·Neuroscience Letters·G Deuschl, M Illert

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