PMID: 3758141Jan 1, 1986Paper

Effects of spironolactone on serum and muscle electrolytes in patients on long-term diuretic therapy for congestive heart failure and/or arterial hypertension

European Journal of Clinical Pharmacology
T DycknerL Widman

Abstract

The effect of adding spironolactone (Aldactone) on muscle electrolytes was studied in 48 patients with arterial hypertension and/or congestive heart failure who had received conventional diuretic treatment, including a potassium supplement, for more than 1 year. After 6 months on spironolactone 100 mg/day as well as the original conventional diuretic therapy, there was a significant increase in both skeletal muscle potassium and magnesium. At the same time these parameters decreased in the control group. In the spironolactone group there was also a significant increase in the mean serum potassium and creatinine levels. There was a significant fall in blood pressure in the spironolactone-treated group.

References

Sep 11, 1982·Lancet·G A MacGregorG A Sagnella
Jun 11, 1983·British Medical Journal·T Dyckner, P O Wester
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Citations

Jan 1, 1988·European Journal of Clinical Pharmacology·K F WhyteJ L Reid
Jan 1, 1988·European Journal of Clinical Pharmacology·L WidmannP O Wester
Jan 29, 2008·Current Heart Failure Reports·Anil Verma, Scott D Solomon
Dec 14, 2005·Mayo Clinic Proceedings·W H Wilson TangGary S Francis
Jan 11, 2011·The Journal of Clinical Hypertension·Domenic A Sica, John M Flack
Jun 28, 2011·Clinical Endocrinology·Louise A BurtonAllan D Struthers
Jul 5, 2005·Journal of the American College of Cardiology·Peter H LawKarl T Weber
May 28, 2013·The American Journal of Medicine·Louise A BurtonMarion E T McMurdo
Jul 7, 2020·European Journal of Heart Failure·Andreas P KalogeropoulosHal A Skopicki
Jan 1, 1990·DICP : the Annals of Pharmacotherapy·H A Skluth, J G Gums
Jan 1, 1988·Acta Medica Scandinavica·T DycknerL Widman

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