PMID: 16622541Apr 20, 2006Paper

Effects of splenic surgeries on lipidogram of rats

Revista da Associação Médica Brasileira
Andy PetroianuLuiz R Alberti

Abstract

Although the occurrence of spleen alterations in the various forms of dyslipidemia, such as Gaucher's disease, has been well established, the relation between the spleen and lipid metabolism has not been properly studied. In order to contribute to the filling of this gap, in the present investigation we assessed experimentally the lipidogram of rats in the presence of the spleen, in asplenia, and after conservative spleen surgeries. Forty female Wistar rats of similar weight and age were divided into 4 groups submitted to the following procedures: Group 1--control, with an intact spleen; Group 2--total splenectomy; Group 3--subtotal splenectomy, and Group 4--total splenectomy complemented with autogenous spleen tissue implants. Four months after the interventions, serum triglycerides, total cholesterol and fractions (VLDL, LDL, HDL) were determined. The results for the four groups were compared by analysis of variance followed by the Tukey-Kramer test, with the level of significance set at p < 0.05. There were no differences between groups 1, 3 and 4. In the animals submitted to total splenectomy, total cholesterol (p = 0.0093) and LDL fraction concentrations (p < 0.0001) were higher, whereas HDL fraction concentrations were lo...Continue Reading

Citations

May 17, 2007·Acta Cirúrgica Brasileira·Isabel Cristina Andreatta Lemos PauloAlcino Lázaro da Silva
May 6, 2009·Lipids·Ana Paula Gonçalves DinisMargareth Crisóstomo Portela
Jun 12, 2014·Revista do Colégio Brasileiro de Cirurgiões·Thiago Barbosa GonçalvesAndy Petroianu
Mar 6, 2009·The Journal of Veterinary Medical Science·Jun-ichi Suto
Apr 11, 2015·Arquivos Brasileiros De Cirurgia Digestiva : ABCD = Brazilian Archives of Digestive Surgery·Alcino Lázaro da Silva
Aug 17, 2018·Lipids in Health and Disease·Xiao-Ming AiNian-Yin Yang
May 4, 2011·Acta Cirúrgica Brasileira·Marcela Souza Lima PauloDanilo Nagib Salomão Paulo
Oct 21, 2020·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Yuksel AltinelHafize Uzun
Nov 26, 2020·Acta Cirúrgica Brasileira·Andréa Saade Daher BorjailiTarcizo Afonso Nunes
Nov 7, 2021·Scientific Reports·Kelly Renata Sabino, Andy Petroianu

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