Effects of spontaneous and hypercapnic hyperventilation on inspiratory effort sensation in normal subjects

American Journal of Respiratory and Critical Care Medicine
E L De VitoF Pessolano

Abstract

In order to elucidate if the inspiratory effort sensation (IES) associated with carbon dioxide (CO2) is independent of the concomitant increase in the ventilation, we studied 23 normal resting volunteers (mean age 34 +/- 11 yr) during CO2 rebreathing. Our main goal was to compare the IES at the same ventilation level under hypercapnic and isocapnic conditions. The protocol included: (1) basal measurements (BASAL); (2) hypercapnic ventilation (HV); (3) screen copy of ventilatory pattern during hypercapnia (COPY); (4) screen copy at basal end-tidal (partial) carbon dioxide pressure (PETCO2) (ISO); and (5) recovery (REC). During HV, PETCO2 increased to 54.8 +/- 0.78 mm Hg (p < 0.001) and ventilation (VE) from 12.0 +/- 0.50 to 28.1 +/- 1.19 L/min (p < 0.001). Borg value increased from 0.11 +/- 0.06 to 3.4 +/- 0.23 (p < 0.001). These values were not different during HV and COPY. During ISO, PETCO2 was 40.2 +/- 0. 59 mm Hg (not significant [NS] from BASAL), while VE remained unchanged: 29.9 +/- 1.29 L/min (NS from HV and COPY). Interestingly, the Borg value during the ISO decreased to 1.86 +/- 0.28 (p < 0.001 compared with HV and COPY). The increased IES induced by hypercapnic ventilation was reduced at the same ventilation level dur...Continue Reading

References

Nov 1, 1992·The American Review of Respiratory Disease·B H DemediukR M Schwartzstein
Apr 1, 1989·Respiration Physiology·R B BanzettR Brown
Mar 1, 1954·Journal of Applied Physiology·W S FOWLER
Sep 1, 1964·The American Journal of Medicine·H A KONTOSJ L PATTERSON

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Citations

Nov 9, 2000·American Journal of Respiratory and Critical Care Medicine·R W LansingR B Banzett
Jan 20, 2007·Journal for Specialists in Pediatric Nursing : JSPN·Ellen B BucknerLinda Gibson
Aug 2, 2017·American Journal of Respiratory and Critical Care Medicine·Santiago C Arce, Eduardo L De Vito
Sep 21, 2019·Physiological Reviews·Eoin P CumminsCormac T Taylor

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