Effects of SS320A, a new cysteine derivative, on the change in the number of goblet cells induced by isoproterenol in rat tracheal epithelium

Japanese Journal of Pharmacology
K TakahashiT Miyata

Abstract

We examined the effects of SS320A ((-)-(R)-2-amino-3-(3-hydroxypropylthio)propionic acid), a new cysteine derivative, on the change in the number of goblet cells induced by isoproterenol in rat tracheal epithelium. Four types of goblet cells were characterized in tracheal epithelium according to their size and staining affinity with Alcian blue (AB) / periodic acid Schiff (PAS). When each rat was given a single daily injection of isoproterenol (0.05 mg/kg, i.p.) for 14 days, a significant increase was observed in AB/PAS-positive cells that were recognizable as goblet cells in tracheal epithelium. When SS320A (10-100 mg/kg, p.o.) or propranolol (1 mg/kg, s.c.) was administered before each injection of isoproterenol, the increase in the number of goblet cells induced by isoproterenol was significantly inhibited. There was no difference between male and female rats with regard to this inhibitory action. On the other hand, ambroxol, bromhexine, L-cysteine ethyl ester and S-carboxymethylcysteine (100 mg/kg, p.o., respectively), which are used as expectorants, had no inhibitory effects on the isoproterenol-induced change in the number of goblet cells. Four metabolites (M1-M4) of SS320A in rats also failed to inhibit the change induce...Continue Reading

References

Apr 1, 1978·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·A KodaH Mori
Nov 27, 1991·Biochemical and Biophysical Research Communications·B JanyC Basbaum
Jan 1, 1990·Annual Review of Physiology·C B BasbaumW E Finkbeiner
Feb 1, 1990·The Journal of Allergy and Clinical Immunology·J D Lundgren, J H Shelhamer
Jan 1, 1988·Experimental Lung Research·J D LundgrenJ H Shelhamer
Apr 1, 1987·The American Review of Respiratory Disease·P D ScanlonJ M Drazen
Sep 1, 1994·The European Respiratory Journal·M L Lohmann-MatthesG Franke-Ullmann
May 1, 1996·The American Journal of Physiology·K GuzmanP Nettesheim

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Citations

Aug 11, 2006·European Journal of Drug Metabolism and Pharmacokinetics·H Y JiaoY Chen
Dec 5, 2008·Expert Opinion on Investigational Drugs·Sabina Antonela Antoniu
Jan 15, 2005·Pulmonary Pharmacology & Therapeutics·H KomatsuT Okumoto
May 11, 2010·Journal of Pharmacological Sciences·Yuki NishimotoYoichiro Isohama
Jun 29, 2001·The Journal of Pharmacy and Pharmacology·K TakahashiT Miyata

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