PMID: 6397287Jul 1, 1984Paper

Effects of starvation on phospholipid metabolism of pancreatic islets

Diabetes Research
A Hallberg, A Andersson

Abstract

It was the aim of the present study to examine the extent to which starvation-induced impairment of glucose-stimulated insulin secretion is linked to changes of islet phospholipid metabolism. For this purpose both islets isolated from mice starved for 60 hr and islets maintained in culture for 1 week in a low (3.3 mM) glucose medium were studied together with relevant control islets. When challenged with a high glucose concentration the insulin response of both groups of islets was totally blunted. The effect of food restriction on 14C-glucose incorporation into different phospholipid classes was less prominent. On a percentage basis phosphatidylserine biosynthesis of islets isolated from starved mice was most affected, whereas the biosynthesis of phosphatidylcholine was only marginally impaired. Culture of islets for 1 week at the low glucose concentration affected the phospholipid biosynthesis even less and there was only a small decrease of 14C-glucose incorporation into phosphatidylcholine. In general, cultured islets synthesized more phospholipids than the freshly isolated ones. No dose-response relationship was found between various degrees of glucose-stimulated insulin secretion and 14C-glucose incorporation into differe...Continue Reading

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