Effects of Statin Intensity on Clinical Outcome in Acute Myocardial Infarction Patients

Circulation Journal : Official Journal of the Japanese Circulation Society
Doyeon HwangKAMIR Investigators

Abstract

There has been debate regarding the added benefit of high-intensity statins compared with low-moderate-intensity statins, especially in patients with acute myocardial infarction (AMI).Methods and Results:The Korea Acute Myocardial Infarction Registry-National Institutes of Health consecutively enrolled 13,104 AMI patients. Of these, a total of 12,182 patients, who completed 1-year follow-up, were included in this study, and all patients were classified into 3 groups (no statin; low-moderate-intensity statin; and high-intensity statin). The primary outcome was major adverse cardiac event (MACE) including cardiac death, non-fatal MI, and repeat revascularization at 1 year. Both low-moderate-intensity and high-intensity statin significantly reduced low-density lipoprotein cholesterol (LDL-C; all P<0.001). Compared with the no statin group, both statin groups had significantly lower risk of MACE (low-moderate intensity: HR, 0.506; 95% CI: 0.413-0.619, P<0.001; high intensity: HR, 0.464; 95% CI: 0.352-0.611, P<0.001). The risk of MACE, however, was similar between the low-moderate- and high-intensity statin groups (HR, 0.917; 95% CI: 0.760-1.107, P=0.368). Multivariable adjustment, propensity score matching, and inverse probability ...Continue Reading

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Citations

Nov 23, 2018·Circulation Journal : Official Journal of the Japanese Circulation Society·Doyeon HwangUNKNOWN KAMIR Investigators
Aug 22, 2020·Journal of Lipid and Atherosclerosis·Doo Sun SimUNKNOWN Korea Acute Myocardial Infarction Registry-National Institutes of Health (KAMIR-NIH) registry investigators
Nov 25, 2020·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·So Young KimHyo Geun Choi
Jul 5, 2021·European Journal of Pharmacology·Leonid N MaslovPeter R Oeltgen

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