Effects of stem cell therapy on protein profile of parkinsonian rats using an(18) O-labeling quantitative proteomic approach

Proteomics
Yahui LiuHong Qing

Abstract

The application of neural stem cell (NSC) research to neurodegenerative diseases has led to promising clinical trials. Currently, NSC therapy is most promising for Parkinson's disease (PD). We conducted behavioral tests and immunoassays for the profiling of a PD model in rats to assess the therapeutic effects of NSC treatments. Further, using a multiple sample comparison workflow, combined with (18) O-labeled proteome mixtures, we compared the differentially expressed proteins from control, PD, and NSC-treated PD rats. The results were analyzed bioinformatically and verified by Western blot. Based on our initial findings, we believe that the proteomic approach is a valuable tool in evaluating the therapeutic effects of NSC transplantation on neurodegenerative disorders.

References

Apr 1, 1981·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S M HsuH Fanger
Jan 5, 2005·The Journal of Clinical Investigation·Yasushi TakagiNobuo Hashimoto
Dec 5, 2008·Journal of Proteome Research·Wei-Jun QianUNKNOWN Inflammation and the Host Response to Injury Large Scale Collaborative Research Program
Jun 1, 2010·Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases·Nicholas J Maragakis
Jul 8, 2010·Molecular Therapy : the Journal of the American Society of Gene Therapy·Shin-ichi MuramatsuImaharu Nakano
Aug 7, 2010·Journal of Proteome Research·Silvia SchiareaChiara Chiabrando
Mar 15, 2011·Annals of Neurology·Min ShiJing Zhang
Sep 10, 2011·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Genevieve Gowing, Clive N Svendsen
Sep 13, 2011·International Review of Neurobiology·L K PrashanthWassilios G Meissner
Sep 20, 2011·Journal of Biotechnology·Tiziana Alberio, Mauro Fasano
Feb 2, 2012·Molecular Therapy : the Journal of the American Society of Gene Therapy·Erik CederfjällTomas Björklund
Jun 22, 2012·Trends in Neurosciences·Steven J Coultrap, K Ulrich Bayer
Jan 10, 2013·Experimental Neurology·Fahad AliRoger A Barker
Sep 21, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Elias B IssaJames J DiCarlo
Dec 21, 2013·Molecular Therapy : the Journal of the American Society of Gene Therapy·Raymond T BartusR Jude Samulski
Feb 15, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Hung-Jin HuangCalvin Yu-Chian Chen
Mar 13, 2014·Experimental Neurology·Gretchen M ThomsenClive N Svendsen
Apr 17, 2014·Experimental Neurobiology·Sung S ChoiHong J Lee
May 9, 2014·International Journal of Molecular Sciences·Yahui LiuYulin Deng
May 30, 2014·Nature·Mathias WilhelmBernhard Kuster
Aug 5, 2014·Trends in Neurosciences·A J Robison
Oct 22, 2014·Proceedings of the National Academy of Sciences of the United States of America·Xinjiang KangZhuan Zhou
Mar 15, 2015·Experimental & Molecular Medicine·Leslie M TongYadong Huang

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