Effects of stereotactic neurosurgery on postural instability and gait in Parkinson's disease

Movement Disorders : Official Journal of the Movement Disorder Society
Maaike BakkerBastiaan R Bloem

Abstract

Postural instability and gait disability (PIGD) are disabling signs of Parkinson's disease. Stereotactic surgery aimed at the internal globus pallidus (GPi) or subthalamic nucleus (STN) might improve PIGD, but the precise effects remain unclear. We performed a systematic review of studies that examined the effects of GPi or STN surgery on PIGD. Most studies examined the effects of bilateral GPi stimulation, bilateral STN stimulation, and unilateral pallidotomy; we, therefore, only performed a meta-analysis on these studies. Bilateral GPi stimulation, bilateral STN stimulation, and to a lesser extent, unilateral pallidotomy significantly improved PIGD, and more so during the ON phase than during the OFF phase.

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Citations

Apr 3, 2007·Journal of Neurology·Nieuwboer AliceDesloovere Kaat
Nov 30, 2006·Journal of Neurology·Yasuyuki Okuma
Feb 16, 2008·Journal of Neurology·Jasper E VisserBastiaan R Bloem
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Jun 1, 2011·Movement Disorders : Official Journal of the Movement Disorder Society·John G NuttBastiaan R Bloem
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Oct 26, 2021·Frontiers in Neurology·Hana BrozovaMichele Tagliati

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