PMID: 9181635May 1, 1997Paper

Effects of stimulation of alpha 1-adrenergic and NMDA/glycine-B receptors on learning defects in aged rats

Psychopharmacology
M RiekkinenP Riekkinen

Abstract

The present study was designed to investigate the efficacy of stimulation of alpha1-adrenoceptors and the strychnine insensitive glycine-B binding sites of the N-methyl-D-aspartate (NMDA) receptor complex to alleviate the age-related defect in water maze (WM) spatial (hidden platform) navigation. We found that daily pretraining IP treatment with 2-(2-chloro-5-trifluoromethylphenylamino) imidazole nitrate (ST 587), an alpha1-adrenoceptor agonist, at 3000 micrograms/kg, but not at 1000 micrograms/kg, facilitated acquisition of water maze spatial navigation in aged rats. However, ST 587 3000 micrograms/kg (IP) did not stimulate WM spatial reversal learning or cue navigation to a visible platform in aged rats. A partial strychnine insensitive glycine-B binding site agonist, D-cycloserine (DCS) at 10000 micrograms/kg stimulated acquisition of WM navigation, but had no effect on reversal learning or cue navigation. DCS at 1000 or 3000 micrograms/kg (IP) had no marked effect on WM spatial navigation, and did not enhance the WM performance improving effect of ST 587 in aged rats. A subthreshold dose of ST 587 1000 micrograms/kg did not enhance the therapeutic effect of DCS 1000 micrograms/kg. The present results indicate that activatio...Continue Reading

Citations

Feb 5, 2000·Neuroscience·M BjörklundP Riekkinen
Feb 20, 2003·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·J Knauber, W E Müller
Feb 3, 1999·Annals of the New York Academy of Sciences·J A JosephG Cao
Jan 29, 2016·Brain Research·Humberto SalgadoMarco Atzori
Mar 23, 2011·Pharmacology, Biochemistry, and Behavior·Segev Barak, Ina Weiner
Feb 19, 2014·Physiology & Behavior·Anahita Torkaman-BoutorabiMohammad-Reza Zarrindast
Nov 22, 2019·Central Nervous System Agents in Medicinal Chemistry·Peter V Nguyen, Steven A Connor
Oct 30, 2020·Frontiers in Pharmacology·Dianne M Perez
Sep 29, 1999·Pharmacology & Therapeutics·J Sirviö, E MacDonald
Jun 12, 2021·Frontiers in Cell and Developmental Biology·Dianne M Perez

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