PMID: 8614263Jan 1, 1996Paper

Effects of streptozotocin-induced diabetes and insulin treatment on substance P of the rat arterial wall

Life Sciences
R A Markle, D K Walker

Abstract

Substance P (SP) is present in perivascular nerves throughout the mammalian vasculature. Reports of diminished SP levels in nerve and gastrointestinal tissues of diabetic rats led us to examine SP-like immunoreactivity (SP-LI) in large arteries by RIA. Six weeks after inducing diabetes with streptozotocin (STZ), SP-LI was measured in the thoracic aorta, abdominal aorta, and the proximal superior mesenteric artery. In diabetics we measured a doubling (P<0.01) of SP-LI in all three artery wall preparations. This finding was verified in a second experiment which included a subset of diabetics treated daily with insulin for the sixth week of the holding period. Again, we measured a two-fold or greater increase of SP-LI (P<0.01-0.05) in arteries from the diabetics and found that insulin treatment significantly reduced SP-LI (P<0.05). In contrast to reports of diminished SP content in other tissues of diabetic rats, our findings demonstrate that the artery wall experiences at least a two-fold increase of SP-LI in the diabetic state. Furthermore, this elevation of SP-LI is reduced by insulin. We speculate that these changes of arterial wall SP-LI may contribute to altered regulation of the vascular system in the diabetic state.

References

Jul 1, 1976·Diabetes·O P GandaA A Like
Jan 1, 1978·Acta Physiologica Scandinavica·H AarsB A Haswell
Apr 1, 1977·Acta Physiologica Scandinavica·P Thoren, J V Jones
Nov 1, 1991·Microvascular Research·E S ChungH F Cuénoud
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May 1, 1993·General Pharmacology·J Donnerer, R Amann

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Citations

May 22, 2010·International Urology and Nephrology·Yongzhi LiYili Liu
Apr 20, 2006·Critical Reviews in Food Science and Nutrition·M N Satyanarayana
Dec 3, 2004·Journal of the Peripheral Nervous System : JPNS·Bayarchimeg BatbayarErzsébet Fehér
Dec 8, 2006·Annals of the New York Academy of Sciences·Erzsébet FehérTivadar Zelles
Mar 12, 2010·Journal of Clinical Pharmacology·Kenneth MaieseJinling Hou

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