Effects of streptozotocin-induced diabetes on fetal development of the rat

Teratology
E GiaviniC Vismara

Abstract

The purpose of this study was to determine whether or not in rats with experimentally induced diabetes there is an increased frequency of congenital malformations; data in the literature are not consistent on this point. Virgin CD females rats were injected with 40-50 mg/kg streptozotocin (Stz) before mating (SIBM group) or on the first day of pregnancy (SI1). Both SIBM and SI1 females were divided into two groups according to their blood glucose levels: severely diabetic (SD, greater than 300 mg%) and mildly diabetic (MD, 120-250 mg%). Food and water consumption by the control and MD groups were the same, but the SD females developed polyphagia, polyuria, and polydypsia, which continued to increase throughout pregnancy, as did the blood glucose levels. All the MD females mated and carried to term. In SD females both frequency of mating and fertility were only slightly lower than in the controls. All the females were killed on the 21st day of pregnancy. Pre- and postimplantation losses were the same for diabetic and control rats, but SIBM-SD females ovulated less than other groups. Weights of fetuses of SD dams were lower and blood sugar levels higher than those of the other groups. The placentas of SD rats were significantly h...Continue Reading

References

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Citations

Jan 19, 2000·Pediatric Pulmonology·J ThulesenL Raaberg
Apr 1, 1995·Diabetes/metabolism Reviews·U J Eriksson
Jan 1, 1989·Reproductive Toxicology·H SpielmannB Tenschert
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Mar 14, 2008·The Review of Diabetic Studies : RDS·Arkady Torchinsky, Vladimir Toder
May 14, 2014·Reproduction : the Official Journal of the Society for the Study of Fertility·Elisa HauckeAnne Navarrete Santos
Apr 15, 1995·Experientia·E MenegolaE Giavini
Jan 27, 2009·Regulatory Toxicology and Pharmacology : RTP·Rodrigo Juliano OliveiraMário Sérgio Mantovani
Apr 28, 2016·Upsala Journal of Medical Sciences·Ulf J Eriksson, Parri Wentzel
Jun 25, 2002·Biology of Reproduction·Shannondoah A ColtonStephen M Downs
Dec 6, 2005·Journal of the Society for Gynecologic Investigation·Zhiyong Zhao, E Albert Reece
Apr 7, 2006·Nature·A CoppaR Macchiarelli
Nov 30, 2000·Upsala Journal of Medical Sciences·U J ErikssonP Wentzel
Oct 3, 1998·American Journal of Obstetrics and Gynecology·H ForsbergU J Eriksson

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