PMID: 8597402Dec 29, 1995Paper

Effects of stress on neurotrophic factor expression in the rat brain

Annals of the New York Academy of Sciences
M A SmithR M Post

Abstract

Changes in neurotrophic factor expression in the brain are part of the stress response. Decreased BDNF may contribute to hippocampal damage that occurs during chronic stress or aging. Stress-induced increases in NT-3 may be important for neural plasticity and adaptation or sensitization to repeated stress. Stress-induced changes in neurotrophic factors may be particularly relevant to the cognitive changes that occur in recurrent depression, aging, and posttraumatic stress disorder.

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