Effects of strict blood pressure control by a long-acting calcium channel blocker on brain natriuretic peptide and urinary albumin excretion rate in Japanese hypertensive patients

Hypertension Research : Official Journal of the Japanese Society of Hypertension
Hideyuki UnoKazuomi Kario

Abstract

Strong adherence to antihypertensive therapy has been shown to reduce the frequency of cardiovascular events by strictly controlling blood pressure. Although calcium channel blockers (CCBs) are among the most popular antihypertensive drugs in Japan, few trials have been conducted using high CCB doses in Japanese patients. In this study, we administered amlodipine 5 mg or 10 mg to patients with hypertension in order to compare the efficacy and tolerability of low and high doses, and measured two surrogate markers of hypertensive target organ damage, i.e., brain natriuretic peptide (BNP) as a risk marker of cardiac overload and microalbuminuria as a measure of renal damage. Seventy-two patients were randomly assigned to either amlodipine 5 mg (n = 35) or 10 mg (n = 37) dose groups. The latter group achieved greater reductions in clinic as well as both morning and evening home BP levels without an increase in pulse rate (the differences between the two groups in clinic/morning/evening systolic BP were 4.7/4.7/5.4 mmHg, and for diastolic BP they were 4.2/3.6/3.8 mmHg). Reductions in BNP and urinary albumin/creatinine ratio (UAR) levels were significantly correlated with the reductions in systolic BP levels (BNP, clinic/morning BP: ...Continue Reading

References

Jan 1, 1976·Birth Defects Original Article Series·F H Ruddle, P Meera Khan
Feb 1, 1989·Journal of Internal Medicine·M H FrickH M Tyler
Nov 1, 1988·Journal of Clinical Pharmacology·D M Williams, L X Cubeddu
Sep 1, 1994·Clinical Pharmacology and Therapeutics·G RanieriR De Cesaris
Sep 1, 1993·Clinical Pharmacology and Therapeutics·R DonnellyH L Elliott
Jul 26, 1997·Lancet·K MatsubayashiT Ozawa
Feb 19, 2000·Hypertension·R PedrinelliM Mariani
Dec 29, 2000·Hypertension Research : Official Journal of the Japanese Society of Hypertension·S KatayamaR Kikkawa
Jul 31, 2001·JAMA : the Journal of the American Medical Association·H C GersteinUNKNOWN HOPE Study Investigators
Apr 2, 2002·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Atsushi HozawaYutaka Imai
Oct 3, 2002·Circulation·Hans L HillegeUNKNOWN Prevention of Renal and Vascular End Stage Disease (PREVEND) Study Group
Dec 20, 2002·JAMA : the Journal of the American Medical Association·UNKNOWN ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group. The Antihypertensive and Lipid-Lowering Treatm
Apr 5, 2003·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Kizuku KuramotoToshio Ogihara
May 16, 2003·JAMA : the Journal of the American Medical Association·Aram V ChobanianUNKNOWN National High Blood Pressure Education Program Coordinating Committee
Nov 5, 2003·Journal of Hypertension·Judith A Whitworth, UNKNOWN World Health Organization, International Society of Hypertension Writing Group
Nov 19, 2003·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Yutaka ImaiUNKNOWN Japanese Society of Hypertension
Jan 31, 2004·American Journal of Hypertension·Kazuo EguchiKazuyuki Shimada
Feb 13, 2004·The New England Journal of Medicine·Thomas J WangRamachandran S Vasan
Sep 15, 2004·American Journal of Hypertension·Fabio AngeliCarlo Porcellati
Jun 1, 2005·European Journal of Heart Failure·Eric StantonUNKNOWN PRAISE-2 study investigators
Jan 1, 1991·Journal of Cardiovascular Pharmacology·J Varrone, UNKNOWN Investigators of Study AML-NY-86-002
Jan 1, 1991·Journal of Cardiovascular Pharmacology·I H Osterloh
Aug 31, 2006·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Toyofumi YoshiiMasatsugu Horiuchi

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Citations

Nov 8, 2011·Journal of Atherosclerosis and Thrombosis·Hisashi MasugataFuminori Goda
Nov 16, 2013·Vascular Health and Risk Management·Kazuomi KarioBarrett W Jeffers
Nov 4, 2016·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Ron T GansevoortUNKNOWN TEMPO 3:4 Investigators

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