Effects of sub-minimal inhibitory concentrations of antimicrobial agents on the cell surface of Klebsiella pneumoniae and phagocytic killing activity

Journal of Chemotherapy
S NomuraA Nagayama

Abstract

Changes in the phagocytic killing activity, capsule structure, and physicochemical properties such as the hydrophobicity and charge of the cell surface were studied in Klebsiella pneumoniae treated with sub-minimal inhibitory concentrations (MICs) of various antimicrobial agents. The phagocytic killing activity of macrophages was enhanced by penicillins, cephems, and monobactam in the absence of antibodies specific to the capsule or complement. No enhancement was observed with new quinolones, aminoglycosides, macrolide, or carbapenem. The thickness of the capsule structure was considerably reduced after the treatment with penicillins, cephems, and monobactam compared with the untreated control, and it was slightly reduced by new quinolones. No changes were observed in the capsule structure with aminoglycosides, macrolide, and carbapenem. The hydrophobicity on the cell surface of the bacteria was considerably increased after the treatment with penicillins, cephems, and monobactam compared with the control, slightly increased with new quinolones and carbapenem, and not changed with aminoglycosides and macrolide. The negative charge of the cell surface of the bacteria was reduced by penicillins, cephems, and monobactam compared wi...Continue Reading

References

Jan 1, 1978·Annual Review of Microbiology·C J van Oss
Nov 1, 1992·Microbial Pathogenesis·R PodschunU Ullmann
Nov 1, 1991·Journal of General Microbiology·M JacquesF Malouin
Jan 1, 1973·Advances in Microbial Physiology·D V Richmond, D J Fisher

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Citations

Feb 1, 1997·Expert Opinion on Investigational Drugs·H A Kirst

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