Effects of subchronic administration of antidepressants and anxiolytics on levels of the alpha subunits of G proteins in the rat brain

Journal of Neural Transmission
Y Dwivedi, G N Pandey

Abstract

The aim of this study was to examine the effects of subchronic administration of psychoactive drugs on the alpha subunits of G proteins in the rat brain, and also to determine if different classes of psychoactive drugs share a common property, i.e., of altering levels of these proteins. For this purpose, we selected the psychoactive drugs desipramine and phenelzine (antidepressants), lithium (antimanic), alprazolam and buspirone (anxiolytics), and metachlorophenylpiperazine (anxiogenic). The levels of alpha subunits of G proteins (Gs, Gi 1/2, Gq/11) expressed in cortical, hippocampal, and cerebellar brain regions were studied by the Western blot technique. We observed that subchronic treatment with lithium significantly decreased, and with phenelzine significantly increased levels of Gi 1/2 alpha protein in the cortex and the hippocampus. On the other hand, buspirone significantly decreased levels of Gi 1/2 alpha protein only in the cerebellum. Other psychoactive drugs, however, namely desipramine, meta-chlorophenylpiperazine, and alprazolam, did not alter levels of Gs, Gi 1/2, or Gq/11 alpha proteins in any of the brain regions studied. Since other studies have shown the involvement of G proteins in the mechanism of action of ...Continue Reading

References

Jun 1, 1992·The American Journal of Psychiatry·H K Manji
Dec 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·S F ColinE J Nestler
May 10, 1991·Science·M I SimonN Gautam
Feb 25, 1991·European Journal of Pharmacology·P P LiJ J Warsh
Dec 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M Strathmann, M I Simon
Jan 1, 1990·Critical Reviews in Biochemistry and Molecular Biology·L BirnbaumerA M Brown
Oct 1, 1989·The American Journal of Psychiatry·J M BarabanS H Snyder
Mar 31, 1986·The American Journal of Medicine·A S Eison, D L Temple
Jan 1, 1987·Annual Review of Biochemistry·A G Gilman
Nov 1, 1965·The American Journal of Psychiatry·J J Schildkraut
Dec 1, 1965·Archives of General Psychiatry·W E Bunney, J M Davis
Jan 1, 1984·The Journal of Clinical Investigation·A G Gilman
Jan 1, 1984·Neuropsychobiology·P H Andersen, A Geisler
Sep 1, 1996·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·M EmamghoreishiP P Li

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Citations

Aug 10, 2002·Journal of Psychosomatic Research·Todd D Gould, Husseini K Manji
May 3, 2003·Life Sciences·Robert J Donati, Mark M Rasenick
Sep 24, 2002·Neuropharmacology·Nicoletta GaleottiCarla Ghelardini
Apr 7, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Mireille BasselinStanley I Rapoport
Nov 25, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Mireille BasselinStanley I Rapoport
May 19, 2005·Naunyn-Schmiedeberg's Archives of Pharmacology·Virginia L LucaitesDavid L Nelson
Apr 23, 2009·Neurotoxicity Research·Carsten Calaminus, Wolfgang Hauber
Apr 23, 2009·Neurotoxicity Research·Julio C RojasF Gonzalez-Lima
Dec 17, 2009·Journal of Neural Transmission·Ana C BarcelóJorge Horacio Pazo
Nov 11, 2009·Psychopharmacology·Katherine E BurnhamTrevor Sharp
Jun 5, 2014·European Journal of Nuclear Medicine and Molecular Imaging·Monique R BernsenMarion de Jong
May 27, 2010·Brain Structure & Function·Alexander Joseph McDonald, Franco Mascagni
Jul 6, 2010·Psychopharmacology·Ana Franky CarvalhoElisabeth J Van Bockstaele
Jul 26, 2005·Experimental Brain Research·William M StruthersJason Runyan
Aug 4, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Giada VaccaAnthony G Phillips
Mar 24, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Yi-Ling YangKwok-Tung Lu
May 13, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Nora A IsoardiVíctor A Molina
May 13, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Kerry E CulmRonald P Hammer
May 13, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Yogita Chudasama, Trevor W Robbins
Apr 28, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Alejandra M PacchioniLiliana M Cancela

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