Effects of subchronic exposure of monochloramine in drinking water on male rats

Regulatory Toxicology and Pharmacology : RTP
R PoonB Thomas

Abstract

A subchronic rat study with paired-water control was conducted to resolve the question of whether monochloramine at 200 ppm in drinking water can cause reduced body weight gain and other changes observed in earlier investigations. Male Sprague-Dawley rats (93 +/- 5 g) were divided into three groups of 10 rats each: the treatment group was fed drinking water containing 200 ppm monochloramine, the control group was fed bicarbonate-buffered water ad libitum, and the paired-water control rats were given a daily volume of bicarbonate-buffered water equal to that consumed by the monochloramine treatment group. Compared to the control group, rats in the treatment group consumed an average of 42% less fluid and 16% less food over the 13-week treatment period and had 15-20% lower final body weight gain. Similar degrees of reduction in food consumption and body weight gain were observed in the paired-water rats. A decreased liver to body weight ratio occurred in the treatment and paired-water groups. Increased inorganic phosphate, albumin, total protein, and urea nitrogen were detected in sera from both the treatment group and the paired-water groups. The paired-water animals had lower levels of white blood cells and lymphocytes, while t...Continue Reading

References

Jan 1, 1991·Critical Reviews in Toxicology·A Bernard, R R Lauwerys
Mar 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·N W RevisG Holdsworth
Jan 1, 1987·Archives of Environmental Health·C F Lynch
Feb 1, 1986·Toxicology and Applied Pharmacology·G E HatchA G Stead
Jan 1, 1974·Nephron·C M KjellstrandH S Jacob
Jan 1, 1982·Toxicology·R G Price
Jun 1, 1984·Environmental Health Perspectives·R F Henderson
Jan 1, 1984·Journal of Toxicology and Environmental Health·M S Abdel-RahmanR J Bull
Jan 1, 1981·Methods in Enzymology·B Burchell, P Weatherill
Jul 1, 1981·Journal of the History of Medicine and Allied Sciences·H B Burchell
Oct 2, 1981·Science·R B Herberman, J R Ortaldo
Jul 1, 1981·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·J R LubbersJ R Bianchine
Jul 1, 1994·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·B A RotterH Tryphonas
Jul 1, 1993·The Korean Journal of Internal Medicine·H J PyoC W Cha
Mar 1, 1993·Environmental Health Perspectives·R G WonesL A Frohman
May 1, 1996·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·E W AustinR J Bull

❮ Previous
Next ❯

Citations

Jun 15, 2000·Regulatory Toxicology and Pharmacology : RTP·J S NakaiV E Valli

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
R PoonV E Valli
Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
R PoonB Thomas
Kokuritsu Iyakuhin Shokuhin Eisei Kenkyūjo hōkoku = Bulletin of National Institute of Health Sciences
L YunM Hirose
© 2021 Meta ULC. All rights reserved