Effects of subchronic exposure to styrene on the extracellular and tissue levels of dopamine, serotonin and their metabolites in rat brain

Archives of Toxicology
François GagnaireJ-C Micillino

Abstract

At present, there is controversy over the neurotoxic potential of styrene. Several epidemiological and clinical studies have shown that styrene exposure causes alterations of central nervous system functions in humans. Neurotransmitters have been implicated in the pathogenesis of styrene neurotoxicity in rodents. Several studies carried out on postmortem brain tissue suggest that styrene may alter dopaminergic neurotransmission in rabbit or rat brain. Moreover, in vitro studies suggest that both styrene and styrene oxide inhibit the uptake of dopamine (DA) in purified synaptic vesicles prepared from rat brain striata. To date, biochemical studies on animals have explored global tissue levels of neurotransmitters with sub-acute exposures to styrene. However, extracellular levels of neurotransmitters are more closely related to behaviour than are global tissue levels. The present study determined changes in the extracellular concentrations of DA, serotonin (5-HT) and their acid metabolites, dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA) and 5-hydroxyindolacetic acid (5-HIAA), in striatal dialysates from freely moving adult male rats after exposure to 750 and 1,000 ppm styrene, 6 h per day, 5 days per week for 4 weeks...Continue Reading

References

Jan 1, 1992·Neurotoxicology and Teratology·P Arlien-SøborgL Simonsen
Nov 1, 1992·Toxicology Letters·R KishiH Miyake
Aug 1, 1992·British Journal of Industrial Medicine·H CheckowayR L Dills
Jul 18, 1989·European Journal of Pharmacology·Y L Hurd, U Ungerstedt
Jan 1, 1985·Archives of Toxicology. Supplement. = Archiv Für Toxikologie. Supplement·A MuttiI Franchini
Oct 1, 1986·Physiology & Behavior·J P Kroon, A L Riley
Dec 1, 1986·Journal of Applied Toxicology : JAT·A RomanelliI Franchini
Apr 1, 1985·Archives of Toxicology·R HusainP K Seth
Sep 1, 1984·Archives of Toxicology·A MuttiI Franchini
Nov 1, 1984·British Journal of Industrial Medicine·A MuttiI Franchini
Jan 1, 1994·Critical Reviews in Toxicology·C S Rebert, T A Hall
Sep 1, 1994·Journal of Applied Toxicology : JAT·V K KhannaP K Seth
Jan 1, 1994·Journal of Neural Transmission. Parkinson's Disease and Dementia Section·T BrannanM D Yahr
Jan 1, 1994·International Archives of Occupational and Environmental Health·H CheckowayL G Costa
Aug 15, 1995·European Journal of Pharmacology·J Ichikawa, H Y Meltzer
Oct 1, 1996·American Journal of Epidemiology·E WelpR Saracci
Jan 1, 1997·International Archives of Occupational and Environmental Health·E BergamaschiD Mergler
Jan 1, 1995·Journal of Neural Transmission. Parkinson's Disease and Dementia Section·T BrannanM D Yahr
Jan 29, 1999·Journal of Toxicology and Environmental Health. Part a·T CocciniL G Costa
Mar 20, 1999·Biochemical and Biophysical Research Communications·S K Chakrabarti
May 20, 1999·Journal of Affective Disorders·O CuretB Scatton
Jun 4, 1999·Toxicology Letters·Y KatakuraH Miyake
Aug 10, 1999·Neurotoxicology and Teratology·P CampoM Roure
Feb 21, 2002·Progress in Neuro-psychopharmacology & Biological Psychiatry·Jean Gerardy, Albert Dresse
Dec 8, 2004·Toxicological Reviews·Richard B LomaxMaureen Meldrum

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Citations

Jan 28, 2014·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Carolin Simone FischerMichael Strupp
Jan 1, 2011·ISRN Otolaryngology·Kamakshi V GopalGuenter W Gross
Mar 30, 2010·Neuroscience Letters·Raquel MauriñoMarti Santiago
Sep 26, 2015·Critical Reviews in Toxicology·Heinz-Peter GelbkeSusan Leanne Samson
Mar 12, 2015·Pharmacology, Biochemistry, and Behavior·Susan Schenk, Sarah Bradbury
Apr 23, 2019·Environmental Health Perspectives·Emily J WerderLawrence S Engel
May 14, 2010·The American Journal of Clinical Nutrition·Katharina BuckJenny Chang-Claude
Oct 5, 2010·Nutrition Reviews·Julia PetersonMarjorie L McCullough
Feb 27, 2014·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Verónica MiguelAna I Álvarez
Jan 13, 2016·Biorheology·Mikhail Y MaslovMark B Plotnikov
Jul 10, 2019·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·M I BantonS S Sarang
Jun 1, 2021·Translational Neuroscience·Dandong HuJi Zhang

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