Effects of subchronic exposure to diethylstilbestrol on humoral immune function in adult female (C3B6)F1 mice

Immunopharmacology
P H BickM P Holsapple

Abstract

Adult female (C57BL/6 X C3H)F1 (B6C3F1) mice were treated with diethylstilbestrol for 14 days and assayed for the ability to produce antibody to a T-dependent antigen, a T-independent antigen, and to respond in vitro to stimulation by a polyclonal activator, bacterial lipopolysaccharide (LPS). No suppression of the in vivo antibody responses were observed. DES produced a subtle alteration in the response to the T-dependent antigen, sheep erythrocyte (sRBC), as treated groups maintained higher PFC values than vehicle groups after the peak day of the response. DES induced an enhanced response to the T-independent antigen, DNP-Ficoll. Spleen cells from DES-exposed animals were only marginally altered in their ability to produce antibody in vitro in response to LPS. Parallel experiments indicated a comparable reduction of LPS-induced blastogenesis. Serum immunoglobulin levels were determined following DES exposure, as a measure of baseline immunocompetence. DES only caused a reduction in the immunoglobulin M (IgM) isotype. DES exposure caused a significant enhancement of the activity of the reticuloendothelial (RES) system. Experiments were performed to assess the effects of enhanced RES function on concentrations of 51Cr labeled s...Continue Reading

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Citations

Jan 1, 1989·Developmental and Comparative Immunology·I Berczi
Oct 1, 1986·Immunopharmacology·E Nagy, I Berczi
Jan 1, 1985·Journal of Toxicology and Environmental Health·G M ShoppM P Holsapple
Jan 1, 1987·International Journal of Immunopharmacology·G J RosenthalM I Luster
Dec 1, 1984·The Journal of Experimental Zoology·B Glick
Jan 19, 2002·International Journal of Toxicology·P SinghB L Blaylock
Dec 1, 1990·Endocrine Pathology·Berczi Istvan
Sep 15, 1990·Toxicology and Applied Pharmacology·W CaoA E Munson

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