Effects of subchronic perfluorooctane sulfonate exposure of rats on calcium-dependent signaling molecules in the brain tissue

Archives of Toxicology
Xiaohui LiuHongyao Yu

Abstract

Perfluorooctane sulfonate (PFOS) is a persistent and bio-accumulative pollutant ubiquitous in wildlife and humans, which receives many concerns on the fate, transport, distribution, and toxicity. Studies have shown that PFOS-induced neurotoxicity in experimental animals; however, little is known about the potential mechanism of PFOS exposure on the central nervous system (CNS). Ca(2+)/calmodulin-dependent protein kinase IIalpha (CaMKIIalpha), cAMP-response element binding protein (CREB), c-fos, and c-jun, which are important down-stream molecules of calcium signaling in describing neuron cells structure and function in the CNS, were examined in the paper with the purpose to evaluate the effect of PFOS exposure on brain and approach the molecular mechanisms involved in the neurotoxicity induced by PFOS. Adult male Sprague-Dawley rats were administered with PFOS at dosages of 1.7, 5.0, and 15.0 mg/L in drinking water for 91 consecutive days. LC/MS was used for PFOS analysis in brain tissues, and western blot was employed to determine the expression of CaMKIIalpha and pCREB in the isolated cortex and hippocampus. The expression of c-fos and c-jun was detected by real-time reverse transcription polymerase chain reaction. The result...Continue Reading

References

May 1, 1977·Analytical Biochemistry·J J Sedmak, S E Grossberg
Jan 1, 1991·Annual Review of Biochemistry·H R Herschman
May 2, 2001·Environmental Science & Technology·K KannanJ P Giesy
May 15, 2001·Environmental Science & Technology·K J HansenH O Johnson
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Dec 31, 2002·Toxicology·Andrew M SeacatJohn L Butenhoff
Feb 8, 2003·Brain Research. Molecular Brain Research·Aiguo Wu, Yugu Liu
Sep 2, 2003·Environmental Health Perspectives·Maureen E AustinSheba M J MohanKumar
Jul 9, 2004·Toxicology and Applied Pharmacology·Christopher LauJohn M Rogers
Mar 2, 2005·Biochemical and Biophysical Research Communications·Kouji HaradaAkio Koizumi
Sep 24, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·Rosemary A SchuhGary Fiskum
Nov 23, 2005·Biochemical and Biophysical Research Communications·Eriko MatsubaraAkio Koizumi
Nov 23, 2005·Neurotoxicology·Noriaki ShimokawaNoriyuki Koibuchi
Oct 24, 2006·Biochemical and Biophysical Research Communications·Kouji H HaradaHarunori Ohmori
May 24, 2007·Toxicological Sciences : an Official Journal of the Society of Toxicology·Christopher LauJennifer Seed
Oct 2, 2007·Neurotoxicology·Lucio G Costa, Gennaro Giordano
Oct 24, 2007·Toxicology·Silvia FuentesJosé L Domingo
Dec 3, 2008·Environmental Toxicology and Chemistry·Wen-Guang YuYi-He Jin
Dec 17, 2008·Chemico-biological Interactions·Da-Qing SunMing-Zhi Gong
Feb 13, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Niclas JohanssonHenrik Viberg
Mar 1, 2007·Environmental Toxicology and Pharmacology·Feige TangXiaoming Shen
Sep 1, 2007·Environmental Toxicology and Pharmacology·Kouji H HaradaAkio Koizumi
May 1, 2009·Environmental Toxicology and Pharmacology·Chun-Yang LiaoGui-Bin Jiang

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Citations

Oct 12, 2012·Archives of Toxicology·H M BoltJ G Hengstler
Mar 26, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Faqi WangJunsheng Ma
Feb 15, 2012·Archives of Toxicology·C van ThrielR Marchan
Aug 16, 2012·Archives of Toxicology·C Van Thriel, J D Stewart
May 25, 2012·Journal of Hazardous Materials·Hongyan LiGuangke Li
Jun 10, 2011·Biochemical and Biophysical Research Communications·Xin WangYu-Hua Chen
May 18, 2011·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Xiaohui LiuShuang Hao
Dec 20, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Yu WangXie Quan
May 29, 2016·Toxicology in Vitro : an International Journal Published in Association with BIBRA·A DomínguezE Bonilla
May 29, 2016·Progress in Neurobiology·Marta C AntonelliStefan Spulber
Nov 9, 2016·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Zhenwei LiJing Shao
Dec 13, 2018·EFSA Journal·UNKNOWN EFSA Panel on Contaminants in the Food Chain (CONTAM)Tanja Schwerdtle
Sep 18, 2021·Environmental Science. Processes & Impacts·Yuexin Cao, Carla Ng

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