Effects of subminimum inhibitory concentrations of antibiotics on the Pasteurella multocida proteome

Journal of Proteome Research
Bindu NanduriShane C Burgess

Abstract

Subminimum inhibitory concentrations (sub-MICs) of antibiotics can be therapeutically effective, but the underlying molecular mechanisms are not well-characterized. We analyzed the Pasteurella multocida proteome response to sub-MICs of amoxicillin, chlortetracycline, and enrofloxacin using isotope-coded affinity tags (ICAT). There were parallel effects on inhibition of growth kinetics and suppression of protein expression by clusters of orthologous groups (COG) categories. Potential compensatory mechanisms enabling antibiotic adaptation were identified, including increased RecA expression caused by enrofloxacin.

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Citations

Nov 26, 2008·Applied and Environmental Microbiology·Janet R DonaldsonMark L Lawrence
Oct 14, 2009·BMC Bioinformatics·Ken PendarvisBindu Nanduri
Oct 14, 2009·BMC Bioinformatics·Bart H J van den BergSusan M Bridges
Dec 6, 2007·BMC Bioinformatics·William S SandersShane C Burgess
Dec 6, 2007·BMC Bioinformatics·Susan M BridgesBindu Nanduri
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Sep 10, 2008·Journal of Agricultural and Food Chemistry·M Gratacós-CubarsíF Jessen

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