Effects of substance P in the amygdala, ventromedial hypothalamus, and periaqueductal gray on fear-potentiated startle.

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
Zuowei ZhaoMichael Davis

Abstract

The neural pathways through which substance P (SP) influences fear and anxiety are poorly understood. However, the amygdala, a brain area repeatedly implicated in fear and anxiety processes, is known to contain large numbers of SP-containing neurons and SP receptors. Several studies have implicated SP neurotransmission within the amygdala in anxiety processes. In the present study, we evaluated the effects of site-specific infusions of an SP receptor antagonist, GR 82334, on conditioned fear responses using the fear-potentiated startle paradigm. GR 82334 infusion into the basolateral (BLA) or the medial (MeA) nuclei of the amygdala, but not into the central nucleus of the amygdala (CeA), dose dependently reduced fear-potentiated startle. Similar effects were obtained with GR 82334 infusion into the ventromedial nucleus of the hypothalamus (VMH), to which the MeA projects, and into the rostral dorsolateral periaqueductal gray (PAG), to which the VMH projects, but not into the deep layers of the superior colliculus/deep mesencephalic nucleus (dSC/DpMe), an output of the CeA previously shown to be important for fear-potentiated startle. Consistent with previous findings, infusion of the AMPA receptor antagonist, NBQX, into the dSC...Continue Reading

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Citations

Jan 15, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Segev Barak, Ina Weiner
Apr 27, 2010·Journal of Neuropathology and Experimental Neurology·Takahiro FukudaSaburo Saito
Jun 27, 2009·Behavioural Brain Research·Erika KertesLászló Lénárd
Apr 23, 2013·Hormones and Behavior·Karina G BorelliMarcus L Brandão
Jan 10, 2012·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Jonas EngmanMats Fredrikson
Apr 10, 2013·Neurobiology of Learning and Memory·M C CarvalhoM L Brandão
Oct 4, 2014·Frontiers in Neuroscience·Chelsea A VadnieDoo-Sup Choi
May 18, 2012·Psychopharmacology·Michel A SteinerFrancois Jenck
Sep 4, 2015·Journal of Neurophysiology·Ludmila SosulinaHans-Christian Pape
Nov 19, 2019·Neuropeptides·Kanwal IftikharSumbul Zehra

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