PMID: 7537770Feb 9, 1995Paper

Effects of substance P on cardiovascular regulation in the rabbit

Journal of the Autonomic Nervous System
F MartiniJ J Puizillout

Abstract

The effect of substance P on blood pressure and aortic reflex was investigated in rabbits. Microinjections of substance P and Sar9, Met(O2)11-SP (a selective NK1-receptor agonist) into the floor of the fourth ventricle led to a dose-dependent increase of blood pressure and a sharp enhancement of the baroreflex. These effects were abolished by pretreatment with SR 140333 (a selective NK1-receptor antagonist). Intraventricular injection of the antagonist alone significantly decreased the amplitude of the aortic reflex. After bivagotomy, the amplitude of the parasympathetic component of the baroreflex decreased dramatically and substance P injections were no longer effective. Our results demonstrate that substance P activation of NK1 receptors plays a major role in the modulation of the parasympathetic component of the baroceptor reflex.

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Citations

Apr 18, 2002·Autonomic Neuroscience : Basic & Clinical·V John Massari, Musa A Haxhiu
May 28, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Patrick P J van der VeekAd A M Masclee
Jan 27, 2007·Journal of Applied Physiology·Matthew V DzurikDavid Robertson

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