Effects of Sugar-Sweetened, Artificially Sweetened, and Unsweetened Beverages on Cardiometabolic Risk Factors, Body Composition, and Sweet Taste Preference: A Randomized Controlled Trial.

Journal of the American Heart Association
Cara B EbbelingDavid S Ludwig

Abstract

Background A 2018 American Heart Association science advisory indicated that, pending further research, artificially sweetened beverages (ASBs) may be an appropriate initial replacement for sugar-sweetened beverages (SSBs) during transition to unsweetened beverages (USBs). Methods and Results We randomly assigned 203 adults (121 males, 82 females; 91.6% retention), who habitually consumed SSBs, to 3 groups and delivered free SSBs, ASBs, or USBs to their homes for 12 months. Outcomes included serum triglyceride to high-density lipoprotein cholesterol ratio (primary), body weight, and sweet taste preference (experimental assessment, 0%-18% sucrose solutions). Change in serum triglyceride to high-density lipoprotein cholesterol ratio was not different between groups. Although overall change in weight also was not different between groups, we found effect modification (P=0.006) by central adiposity. Among participants in the highest tertile of baseline trunk fat but not other tertiles, weight gain was greater (P=0.002) for the SSB (4.4±1.0 kg, estimate±SE) compared with ASB (0.5±0.9 kg) or USB (-0.2±0.9 kg) group. Both sweetness threshold (-1.0±0.2% m/v; P=0.005) and favorite concentration (-2.3±0.4% m/v; P<0.0001) decreased in the...Continue Reading

Associated Clinical Trials

Feb 14, 2011·David S. Ludwig, MD, PhD, David S. Ludwig, MD, PhD

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Citations

Nov 11, 2020·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Peter J Rogers, Katherine M Appleton
Dec 11, 2020·The American Journal of Clinical Nutrition·Danielle R ReedRichard D Mattes
Jun 2, 2021·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Karen J HofmanShu Wen Ng

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Software Mentioned

Research Electronic Data Capture )
Nutrition Data System for Research
SAS

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