Effects of sulfadimethoxine on tissue distribution of (14C)bilirubin in the newborn and adult hyperbilirubinemic Gunn rate.

Pediatric Research
D R Davis, R A Yeary

Abstract

Sulfadimethoxine significantly reduced plasma bilirubin levels and altered the tissue bilirubin distribution in both the newborn and the adult Gunn rat. The majority of the unbound bilirubin appeared to distribute perferentially to the intestine and liver in the newborn, whereas in the adult the unbound bilirubin was taken up primarily by the liver. The bilirubin content of brain tissue from both age groups was significantly higher after sulfadimethoxine treatment.

Citations

Oct 18, 2000·The Journal of Pediatrics·C E Ahlfors
Apr 25, 2008·Liver International : Official Journal of the International Association for the Study of the Liver·Johan Fevery
Mar 15, 2006·Biology of the Neonate·Carrie CannonJon F Watchko
Nov 25, 2005·Pediatric Research·Charles E Ahlfors, Anne E Parker
Feb 14, 2009·Journal of Perinatology : Official Journal of the California Perinatal Association·M J DaoodJ F Watchko
Sep 8, 2019·Pediatric Research·Giulia Bortolussi, Andrés F Muro
May 9, 2009·Clinical Chemistry·Charles E AhlforsClaudio Tiribelli
Jul 4, 2018·Pediatric Research·Charles E AhlforsDavid K Stevenson
Jan 1, 1980·Brain & Development·L Ballowitz

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