PMID: 20644334Jul 21, 2010Paper

Effects of sulfaphenazole derivatives on cardiac ischemia-reperfusion injury: association of cytochrome P450 activity and infarct size

Journal of Pharmacological Sciences
Yasuhiro IshiharaNorio Shimamoto

Abstract

Cardiac ischemia-reperfusion injury is evoked by reactive oxygen species (ROS). We previously reported that sulfaphenazole (SPZ) attenuated cardiac ROS levels and ischemia-reperfusion injury in rats. SPZ has distinct two actions: a) elimination of ROS and b) inhibition of cytochrome P450 (CYP) that is responsible for ROS production. The aim of this study is to determine which action contributes to the attenuation of cardiac ischemia-reperfusion injury using SPZ and its derivatives [acetyl-SPZ (Ac-SPZ) and dichloro-SPZ (2Cl-SPZ)]. Administration of 2Cl-SPZ or SPZ prior to ischemia significantly reduced myocardial infarct size, myocardial lipid peroxides, and ROS levels. In addition, they inhibited rat cardiac CYP activity. However, Ac-SPZ neither reduced infarct size nor inhibited cardiac CYP activity. The three compounds had similar effects on ROS scavenging activity in that they scarcely scavenged hydrogen peroxide and superoxide anions but reduced hydroxyl radicals with the same efficacy. The serum concentration of each compound was almost the same until 24 h after reperfusion. Collectively, our findings indicate that the suppressive effects of SPZ and 2Cl-SPZ on ischemia-reperfusion injury are associated with the reduction o...Continue Reading

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Apr 10, 2009·European Journal of Pharmacology·Yasuhiro IshiharaNorio Shimamoto

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Citations

Oct 6, 2012·Biological & Pharmaceutical Bulletin·Sayuri HamaKouichi Itoh
Sep 6, 2011·Journal of Bioscience and Bioengineering·Yasuhiro IshiharaKouichi Itoh
Sep 8, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Jing ZhangWen-Hong Ma
May 7, 2016·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Meijuan XuPing Li
Apr 3, 2013·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Norio Shimamoto
Feb 3, 2021·European Journal of Clinical Investigation·Thamonwan DiteepengMarco Luciani
Aug 14, 2012·Archives of Biochemistry and Biophysics·Yasuhiro IshiharaNorio Shimamoto

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