Effects of sulfathiazole, oxytetracycline and chlortetracycline on steroidogenesis in the human adrenocarcinoma (H295R) cell line and freshwater fish Oryzias latipes

Journal of Hazardous Materials
Kyunghee JiJohn P Giesy

Abstract

Pharmaceuticals in the environment are of growing concern for their potential consequences on human and ecosystem health. Alterations in the endocrine system in humans or wildlife are of special interest because these alterations could eventually lead to changes in reproductive fitness. Using the H295R cell line, the potential endocrine disrupting effects of six pharmaceuticals including diclofenac, erythromycin, sulfamethazine, sulfathiazole, oxytetracycline, and chlortetracycline were investigated. After exposure to each target pharmaceutical for 48 h, production of 17beta-estradiol (E2) and testosterone (T), aromatase (CYP19) enzyme activity, or expression of steroidogenic genes were measured. Concentrations of E2 in blood plasma were determined in male Japanese medaka fish after 14 d exposure to sulfathiazole, oxytetracycline, or chlortetracycline. Among the pharmaceuticals studied, sulfathiazole, oxytetracycline and chlortetracycline all significantly affected E2 production by H295R cells. This mechanism of the effect was enhanced aromatase activity and up-regulation of mRNAs for CYP17, CYP19, and 3betaHSD, all of which are important components of steroidogenic pathways. Sulfathiazole was the most potent compound affecting...Continue Reading

References

Jan 11, 2002·Environmental Science & Technology·S A SnyderJ P Giesy
Jun 10, 2004·Toxicological Sciences : an Official Journal of the Society of Toxicology·Klara HilscherovaJohn P Giesy
May 12, 2005·Environmental Science & Technology·Xiaowei ZhangJohn P Giesy
Jun 7, 2005·The Science of the Total Environment·Paul H Roberts, Kevin V Thomas
Nov 1, 2005·Aquatic Toxicology·Karl FentDaniel Caminada
Feb 6, 2008·Toxicology Letters·Yuhe HePaul K S Lam
Jan 13, 2009·Environment International·Marina IsidoriAlfredo Parrella
Jan 14, 2009·The Science of the Total Environment·A J WatkinsonS D Costanzo
Feb 3, 2009·Chemosphere·Klaus Kümmerer

❮ Previous
Next ❯

Citations

Dec 3, 2013·Journal of Pharmaceutical and Biomedical Analysis·Rocío Cazorla-ReyesJosé Luis Martínez Vidal
Nov 13, 2013·Environmental Science and Pollution Research International·Changseok HanDionysios D Dionysiou
Apr 15, 2011·Ecotoxicology and Environmental Safety·Jinyoung LeeKyungho Choi
Aug 19, 2015·Environmental Toxicology and Pharmacology·Viktoriia BurkinaGalia Zamaratskaia
Dec 2, 2020·Environmental Pollution·Sammani RamanayakaMeththika Vithanage

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.