Effects of sulphurous water on human neutrophil elastase release

Therapeutic Advances in Respiratory Disease
Pier Carlo BragaGiuseppe Nappi

Abstract

Molecules bearing a sulphide (HS) group, such as glutathione, play a fundamental role in the defensive system of human airways, as shown by the fact that the lining fluid covering the epithelia of the respiratory tract contains very high concentrations of glutathione: the lungs and nose, respectively, contain about 140 and 40 times the concentrations found in plasma. Consequently, various low-weight soluble molecules bearing an HS group (including N-acetylcysteine, mesna and thiopronine, and prodrugs such as stepronine and erdosteine) have been used for therapeutic purposes. HS groups can also be therapeutically administered by means of sulphurous thermal water containing HS groups. The aim of this study was to investigate the direct activity of such water on the release of elastase by activated human neutrophils. After the neutrophils were incubated with increasing amounts of sulphurous water or the HS/hydrogen sulphide donor sodium hydrosulphide (NaHS), elastase release was initiated by N-formyl-methionyl-leucyl-phenylalanine and measured by means of spectrofluorimetry using methylsuccinylalanylprolylvalyl-methylcoumarin amide as the fluorogenic substrate. To verify the presence of direct action on elastase we determined the ...Continue Reading

References

Dec 1, 1990·Biochemical Pharmacology·G W De VriesL A Wheeler
Dec 1, 1989·The American Review of Respiratory Disease·A B ThompsonS I Rennard
Aug 1, 1989·The American Review of Respiratory Disease·J E Heffner, J E Repine
Mar 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·A P TruettR Snyderman
Jan 1, 1988·Methods in Enzymology·D G Wright
Jul 1, 1987·Journal of Applied Physiology·A M CantinR G Crystal
Jan 1, 1988·Experimental Lung Research·C E Patterson, R A Rhoades
Jan 1, 1985·Annual Review of Medicine·A Janoff
Jan 1, 1980·Annual Review of Biochemistry·J A Badwey, M L Karnovsky
Dec 1, 1994·Environmental Health Perspectives·C E CrossB Halliwell
Mar 21, 1993·Biochimica Et Biophysica Acta·H IwamuraD A Willoughby
Aug 1, 1997·Immunopharmacology and Immunotoxicology·M A MariggiòR Fumarulo
Aug 29, 2000·Immunopharmacology·R A RobbinsJ C Hoyt
Oct 12, 2000·The European Respiratory Journal·I Rahman, W MacNee
Jan 26, 2002·Journal of Natural Products·Senia JohanssonLars Bohlin
Nov 1, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Rui Wang
Jun 29, 2004·Treatments in Respiratory Medicine·Suil Kim, Jay A Nadel
Jul 11, 2006·Pharmacology·Pier Carlo BragaLaura Marabini
Sep 7, 2007·Respiration; International Review of Thoracic Diseases·Pier Carlo BragaGiuseppe Nappi

❮ Previous
Next ❯

Citations

Apr 6, 2012·Respiratory Physiology & Neurobiology·Yahong Chen, Rui Wang
May 10, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Jose Manuel Carbajo, Francisco Maraver
Feb 13, 2019·Acta otorhinolaryngologica Italica : organo ufficiale della Società italiana di otorinolaringologia e chirurgia cervico-facciale·E F M BuijsM Quadrio
Jun 23, 2019·International Journal of Biometeorology·Cecilia CarubbiMarco Vitale
Aug 12, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Nahzli DilekCsaba Szabo

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Respiration; International Review of Thoracic Diseases
Pier Carlo BragaGiuseppe Nappi
International Journal of Pediatric Otorhinolaryngology
Angelo SalamiRenzo Mora
Pharmacological Research : the Official Journal of the Italian Pharmacological Society
Liping FangXinmin Liu
© 2021 Meta ULC. All rights reserved