PMID: 2497479Jan 1, 1989Paper

Effects of sulpiride and chlorpromazine on regional cerebral glucose metabolism in schizophrenic patients as determined by positron emission tomography

Psychopharmacology
G WikS Stone-Elander

Abstract

Positron emission tomography (PET) was used to determine regional brain glucose metabolism in schizophrenic patients (n = 17) before and during neuroleptic treatment. The patients had not been treated with neuroleptics for at least 3 weeks before the first study. All suffered from acute psychotic symptoms and were hospitalized to obtain neuroleptic treatment. After determination of regional brain metabolism without neuroleptic treatment, 11 patients were treated with sulpiride (800 mg/day) and 6 patients were treated with chlorpromazine (400 mg/day) over 5-6 weeks before the second PET investigation. The control group consisted of seven healthy male volunteers, also investigated twice 5 weeks apart. The PET investigation was made with the subject in a resting state. The tracer was uniformly labelled 11C-glucose. The metabolism was determined bilaterally in 15 brain regions cortical, as well as central regions. Metabolic rates differed among the groups. The sulpiride group had lower metabolic rates than the controls and the schizophrenic patients later treated with chlorpromazine. The sulpiride group, in which absolute metabolic rates were determined, were clinically more autistic and chronic than the chlorpromazine group. It wa...Continue Reading

References

Feb 1, 1978·The American Journal of Psychiatry·A Carlsson
Dec 14, 1978·Archiv für Psychiatrie und Nervenkrankheiten·L BjerkenstedtG Sedvall
Jan 1, 1978·Acta Psychiatrica Scandinavica. Supplementum·M AsbergG Sedvall
Apr 1, 1979·The British Journal of Psychiatry : the Journal of Mental Science·S A Montgomery, M Asberg
Jun 1, 1985·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·L E DeLisiM S Buchsbaum
Feb 18, 1985·Brain Research·J M Palacios, K H Wiederhold
Oct 1, 1986·Journal of Neurology, Neurosurgery, and Psychiatry·N D VolkowR Cancro
Feb 1, 1987·Archives of General Psychiatry·R E GurM Kushner
Dec 1, 1987·Acta Psychiatrica Scandinavica·F A WieselS Stone-Elander
Jun 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·L FardeG Sedvall
Jun 1, 1985·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M ReivichA Anand
Jan 1, 1970·Acta Psychiatrica Scandinavica. Supplementum·G M Simpson, J W Angus
Dec 1, 1984·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·G Blomqvist
Sep 1, 1984·Journal of Neurochemistry·G PizzolatoS I Rapoport
Feb 1, 1984·Journal of Computer Assisted Tomography·J LittonM Kesselberg
Feb 1, 1981·Journal of Computer Assisted Tomography·M BergströmL Widén

❮ Previous
Next ❯

Citations

Apr 16, 2013·Psychopharmacology·Roberto VivianiBirgit Abler
Jan 1, 1992·Progress in Neuro-psychopharmacology & Biological Psychiatry·F A Wiesel
Oct 8, 2004·Schizophrenia Research·Sarah M Clinton, James H Meador-Woodruff
Jun 6, 2003·Neuroscience and Biobehavioral Reviews·Albert Hung Choy Wong, Hubert H M Van Tol
Feb 14, 1998·Progress in Neuro-psychopharmacology & Biological Psychiatry·R Gracia MarcoM S Keshavan
Apr 26, 2003·Psychiatry Research·Lara L Davidson, R Walter Heinrichs
Aug 31, 1999·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·C H Fu, P K McGuire
May 4, 1999·Acta Psychiatrica Scandinavica. Supplementum·M S BuchsbaumT C Wei
Dec 1, 1993·Journal of Neurology, Neurosurgery, and Psychiatry·R J DolanR S Frackowiak
Aug 21, 2012·Brain Imaging and Behavior·Derrek P HibarUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Jan 1, 1998·International Journal of Psychiatry in Clinical Practice·F Ortun OS Cervera
Feb 4, 2012·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Edith J LiemburgAndré Aleman
Nov 30, 2010·Schizophrenia Research·Masanori SekimotoKiyohisa Takahashi
Feb 1, 1992·The British Journal of Psychiatry : the Journal of Mental Science·P F LiddleR S Frackowiak

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here