PMID: 8306085Dec 1, 1993

Effects of sumatriptan on the cerebral intraparenchymal microcirculation in the cat

British Journal of Pharmacology
M KobariH Takeda

Abstract

1. Sumatriptan, a 5-hydroxytryptamine (5-HT)1-like receptor agonist, is effective against the headache of migraine. The effects of sumatriptan injected via the carotid artery on the cerebral microcirculation were studied in 10 anaesthetized cats. 2. The local cerebral blood volume (CBV), mean transit time of blood (MTT) and cerebral blood flow (CBF) in the parieto-temporal cortex were measured by a photoelectric method. CBV represents the cumulative dimensions of the cerebral microvessels. 3. Sumatriptan at 5 and 50 micrograms kg-1 had no significant effects on the CBV, MTT, CBF, and mean arterial blood pressure (MABP); 500 micrograms kg-1 of sumatriptan reduced the CBV, prolonged the MTT, and decreased the CBF (approximately -20%) without affecting the MABP. Sumatriptan, 5 mg kg-1, elicited transient reductions in CBV and CBF, which were attributable to the rapid and marked falls of MABP seen with this dose. 4. Thus, while a high dose of sumatriptan (500 micrograms kg-1) exhibits direct vasoconstrictor actions on the cerebral vessels, low doses of sumatriptan, within the therapeutic range, elicit no vasoconstriction. The data do not support a vasoconstrictor action of sumatriptan playing a primary role in reversing the headach...Continue Reading

References

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Citations

May 1, 1992·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·H E ConnorP P Humphrey
Apr 1, 1992·British Journal of Clinical Pharmacology·A K ScottA J Pilgrim
Aug 1, 1992·Cephalalgia : an International Journal of Headache·I JansenJes Olesen
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Oct 1, 1988·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M TomitaI Gerdsen

Related Concepts

Cerebral Blood Flow Imaging
Pathologic Vasoconstriction
Cerebrovascular System
Serotonin
Common Carotid Artery
Brain
Entire Carotid Artery
Status Migrainosus
Microvessels
Baresthesia

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