PMID: 8593536Oct 1, 1995Paper

Effects of superoxide dismutase and catalase during reduction of adrenochrome by DT-diaphorase and NADPH-cytochrome P450 reductase

Biochemical and Molecular Medicine
S Baez, J Segura-Aguilar

Abstract

NADPH-cytochrome1 P450 reductase and DT-diaphorase catalyze and one- and two-electron reduction of adrenochrome to its o-semiquinone and o-hydroquinone, respectively. Under aerobic conditions both adrenochrome o-semiquinone and o-hydroquinone proved to be unstable, undergoing autoxidation with concomitant oxygen consumption and continuous NADPH and NADH oxidation. Molecular oxygen was found to play a predominant role in autoxidation of o-semiquinone during reduction of adrenochrome catalyzed by NADPH-cytochrome P450 reductase. In addition, molecular oxygen, in the presence of manganese, was found to be responsible for the majority of autoxidation of o-semiquinone. However, the role of superoxide radicals in the autoxidation of leucoadrenochrome during the reduction of adrenochrome by DT-diaphorase was found to be predominant. Catalase different significantly with respect to NADPH and NADH oxidation during reduction of adrenochrome catalyzed by NADPH-cytochrome P450 reductase and DT-diaphorase. Catalase increased NADPH oxidation slightly, while NADH oxidation was inhibited during reduction of adrenochrome by NADPH cytochrome P450 reductase and DT-diaphorase, respectively. The presence of manganese in the incubation mixture was f...Continue Reading

Citations

Jun 7, 2012·Archives of Toxicology·Eric V PatridgeAlan C Sartorelli
Dec 2, 2000·Biochimica Et Biophysica Acta·K Polewski
Jun 27, 2008·The Journal of Biological Chemistry·Yue FuZhongtao Zhang
Jul 25, 2000·Biochemical and Biophysical Research Communications·A Dagnino-SubiabreJ Segura-Aguilar
Jan 1, 1998·International Journal of Psychiatry in Clinical Practice·J M Zajecka, J S Ross
Jan 24, 2002·The Journal of Pharmacology and Experimental Therapeutics·Cuiping Chen, Dhiren R Thakker
May 21, 1999·The Australian and New Zealand Journal of Psychiatry·I Hickie
Jul 18, 2006·Chemical Research in Toxicology·Kathryn M AventElizabeth M J Gillam

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