PMID: 8614563Nov 17, 1995Paper

Effects of superoxide dismutase on nitric oxide production during reperfusion after focal cerebral ischemia is rats

Neuroscience Letters
E KumuraH Kosaka

Abstract

To assess the interaction of nitric oxide (NO) and superoxide during reperfusion after cerebral ischemia, we studied the dose effects of superoxide dismutase (SOD) on the levels of nitrosyl hemoglobin and plasma nitrite + nitrate which were increased at 30 min reperfusion after 2 h middle cerebral artery occlusion in rats. SOD was administered at 10 min before reperfusion. With 1, 5 and 10 mg/Kg of SOD, plasma nitrite + nitrate level was decreased by 25 mg/kg of SOD. The same amount of apo enzyme was without effect. These results suggest effect of superoxide in the NO level released during reperfusion after cerebral ischemia.

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Citations

Jan 7, 1998·The American Journal of Cardiology·D L LawsonJ L Mehta
Feb 20, 1998·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·N FukuyamaH Nakazawa
Nov 11, 1998·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M SakuraiK Tabayashi
Feb 23, 1999·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·B SpinnewynP E Chabrier
Sep 15, 1999·Proceedings of the National Academy of Sciences of the United States of America·P E ChabrierS Moncada
Mar 10, 2001·Free Radical Research·H NakazawaH Ishida
Aug 31, 2016·Molecular Medicine Reports·Zhiyou CaiGuanghui Chen
May 13, 1999·Biochimica Et Biophysica Acta·H Kosaka

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