Effects of supplemental cystine or methionine on growth and lifespan of stroke-prone spontaneously hypertensive rats

The British Journal of Nutrition
G Sarwar GilaniRudolf Mueller

Abstract

Stroke-prone spontaneously hypertensive (SHRSP) rats are considered a suitable model for studying the effects of dietary and other environmental factors on human essential hypertension and haemorrhagic stroke. To investigate the suitability of a control diet for this strain of rats, we studied the effects of supplementing casein and soya protein isolate (SPI) with two sulphur amino acids (methionine and cystine) on the growth and lifespan of SHRSP rats. The source of dietary protein and the type of supplemental sulphur amino acid had significant (P < 0.05) effects on food intake and weight gain measured after 31 d of the feeding study, while only the type of supplemental sulphur amino acid had significant effects on mean survival times and the survival rates. On average, the casein groups had higher food intake and weight gain compared with the SPI groups. The methionine-supplemented groups had lower food intake but higher weight gain than the cystine-supplemented groups. Similarly, the methionine-supplemented groups had higher mean survival times and survival rates compared with the cystine-supplemented groups. The data would suggest that a control diet based on cystine-supplemented casein (as recommended for normal healthy ra...Continue Reading

Citations

May 11, 2011·The British Journal of Nutrition·Erlend T AasheimHelga Refsum
Feb 10, 2012·Canadian Journal of Physiology and Pharmacology·Jennifer E SlemmerKatherine T Gottschall-Pass
Oct 24, 2014·Aging Cell·Dongyeop LeeSeung-Jae Lee
Nov 2, 2021·Journal of Nutritional Science and Vitaminology·Kumiko TakemoriTakashi Kometani

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