Effects of supplementation with branched chain amino acids and ornithine aspartate on plasma ammonia and central fatigue during exercise in healthy men

Folia Neuropathologica
Tomasz MikulskiKrzysztof Krzeminski

Abstract

Our previous studies showed only slight improvement in central fatigue, measured indirectly by psychomotor performance, after branched chain amino acids (BCAA) supplementation during various efforts in healthy men. It is hypothesised that hyperammonaemia resulting from amino acids metabolism may attenuate their beneficial effect on psychomotor performance; therefore, the L-ornithine L-aspartate (OA) as an ammonia decreasing agent was used. The aim of this study was to investigate the effectiveness of oral BCAA + OA supplementation to reduce plasma ammonia concentration and enhance psychomotor performance during exhaustive exercise in healthy men. Eleven endurance-trained men (mean age 32.6 ± 1.9 years) performed two sessions (separated by one week) of submaximal cycloergometer exercise for 90 minutes at 60% of maximal oxygen uptake followed by graded exercise until exhaustion with randomised, double-blind supplementation with a total of 16 g BCAA and 12 g OA (BCAA + OA trial) or flavoured water (placebo trial). Before exercise, during both efforts and after 20 minutes of recovery multiple choice reaction time (MCRT), perceived exertion, heart rate and oxygen uptake were measured and venous blood samples were taken for plasma le...Continue Reading

Citations

Nov 6, 2018·Frontiers in Microbiology·Hucong WuGuoqiang Zhu
Aug 3, 2018·Journal of the International Society of Sports Nutrition·Chad M KerksickRichard B Kreider
Jul 21, 2020·Voprosy kurortologii, fizioterapii, i lechebnoĭ fizicheskoĭ kultury·S V Okovityi, E B Shustov
Aug 21, 2018·Nutrition Reviews·Andrea BonviniMarcelo M Rogero
May 29, 2021·Scientific Reports·Hajime OhmuraToshiyuki Takahashi

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