PMID: 16613671Apr 15, 2006Paper

Effects of suramin in combination with cisplatin on growth and metastasis of lung adenocarcinoma xenografts in mice

Ai zheng = Aizheng = Chinese journal of cancer
Ping ZhangXiao-Hua Wang

Abstract

Recent study found angiogenesis plays some important roles in tumor growth and metastasis. This study was to explore the inhibitory effect of angiogenesis inhibitor Suramin in combination with cisplatin (DDP) on the growth and lung metastasis of lung adenocarcinoma LA795 cell xenografts in mice. Highly metastatic LA795 cells were inoculated into the mammary fatty pad of 32 T739 mice to establish lung adenocarcinoma models. Four days after inoculation, the mice were randomized into 4 groups: the mice in control group received intraperitoneal injection of 0.2 ml normal saline everyday; the mice in DDP group received injection of DDP [2 mg. (kg.day)-1] at the 4th, 11th, and 18th days; the mice in Suramin group received injection of Suramin [10 mg. (kg.day)-1] everyday; the mice in combination group received injection of DDP [2 mg. (kg.day)-1] at the 4th, 11th, and 18th days, and Suramin [10 mg. (kg day)-1] everyday. All mice were killed 24 days later. Lung and subcutaneous tumors were examined histologically. The metastatic tumor foci on lung surface were observed, lung weight was measured, the occurrence rate of lung metastasis and the inhibitory rate of metastatic foci were calculated, subcutaneous tumor microvessel density (MVD...Continue Reading

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