Effects of surfactants on the properties of PLGA nanoparticles

Journal of Biomedical Materials Research. Part a
Jyothi U MenonKytai Truong Nguyen

Abstract

The objective of this study was to investigate the physical characteristics of poly(D,L-lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) coated with two surfactants, Pluronic or the commonly used polyvinyl alcohol (PVA); and determine their in vitro efficiency as drug carriers for cancer therapy. Free surfactant cytotoxicity results indicated that Pluronic F127 (PF127) was most cytocompatible among the Pluronics tested and hence chosen for coating PLGA NPs for further studies. Release studies using doxorubicin (DOX) as a drug model showed sustained release of DOX from both PVA- and PF127-coated PLGA NPs (PLGA-PVA and PLGA-PF127, respectively) over 28 days. Further, there was no significant difference in human dermal fibroblasts and human aortic smooth muscle cell survival when exposed to both types of NPs. Cellular uptake studies demonstrated that uptake of both nanoparticle types was dose-dependent for both prostate and breast cancer cells. However, these cancer cells internalized more PLGA-PF127 NPs than PLGA-PVA NPs. Moreover, studies showed that drug-loaded PLGA-PF127 NPs not only killed more cancer cells than drug-loaded PLGA-PVA NPs, but also overcame drug resistance in LNCaP, MDA-MB-231, and MDA-MB-468 cancer cells on...Continue Reading

References

Aug 1, 1998·Journal of Controlled Release : Official Journal of the Controlled Release Society·M F ZambauxC Vigneron
Sep 7, 2000·Journal of Controlled Release : Official Journal of the Controlled Release Society·H S YooT G Park
Jul 11, 2002·Journal of Controlled Release : Official Journal of the Controlled Release Society·Sanjeeb K SahooVinod Labhasetwar
Aug 15, 2002·Journal of Controlled Release : Official Journal of the Controlled Release Society·Alexander V KabanovValery Yu Alakhov
Sep 3, 2002·Advanced Drug Delivery Reviews·Alexander V KabanovValery Yu Alakhov
Jan 1, 2005·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Ugo BilatiEric Doelker
Jan 25, 2005·International Journal of Pharmaceutics·Rubiana M Mainardes, Raul C Evangelista
Aug 5, 2006·Journal of Colloid and Interface Science·M J Santander-OrtegaJ L Ortega-Vinuesa
Feb 13, 2007·Nanomedicine : Nanotechnology, Biology, and Medicine·Nancy A Monteiro-RiviereRobert J Nemanich
Feb 17, 2007·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Evangelos C GryparisKonstantinos Avgoustakis
Apr 17, 2007·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·F TewesI Chourpa
Jun 7, 2008·Journal of Controlled Release : Official Journal of the Controlled Release Society·Elena V Batrakova, Alexander V Kabanov
Mar 31, 2009·Bioorganic & Medicinal Chemistry Letters·Meng-Lei HuanQi-Bing Mei
Apr 4, 2009·Nanomedicine : Nanotechnology, Biology, and Medicine·Jason ParkTarek M Fahmy
Aug 25, 2009·Nanomedicine : Nanotechnology, Biology, and Medicine·Bhanuprasanth KoppoluKytai Truong Nguyen
Oct 10, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·Daria Yu AlakhovaAlexander V Kabanov
Oct 24, 2009·Biomaterials·Todd J HarrisSangeeta N Bhatia
Nov 17, 2009·Journal of Pharmaceutical Sciences·Abdulgader BaoumCory Berkland
May 11, 2010·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yanzhuo ZhangSiling Wang
Jul 23, 2011·Journal of Nanoscience and Nanotechnology·Bhavik ShahKytai T Nguyen

❮ Previous
Next ❯

Citations

Aug 7, 2013·Acta Biomaterialia·Zhiwei XieKytai T Nguyen
Aug 17, 2014·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Daniel WehrungMoses O Oyewumi
Jan 15, 2015·Expert Opinion on Drug Delivery·Raul C Maranhão, Elaine R Tavares
Jul 12, 2014·Drug Delivery·Nusaiba K Al-Nemrawi, Rutesh H Dave
Nov 1, 2015·Nanomedicine : Nanotechnology, Biology, and Medicine·Priya RavikumarConnie C W Hsia
Oct 16, 2012·Journal of Biomedical Materials Research. Part a·Maïté CallewaertV Gaëlle Roullin
Jul 22, 2014·Journal of Biomedical Materials Research. Part a·Manuela F FrascoManuel A N Coelho
Aug 5, 2014·Journal of Biomedical Materials Research. Part a·Jyothi U MenonDebabrata Saha
Feb 12, 2014·Acta Biomaterialia·Jyothi U MenonKytai T Nguyen
Mar 26, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Joana M SilvaHelena F Florindo
Jun 12, 2013·International Journal of Pharmaceutics·Nadège GrabowskiElias Fattal
Dec 17, 2014·International Journal of Pharmaceutics·Chen ShiMarc Schneider
Jul 12, 2016·International Journal of Biological Macromolecules·Nancy M ElbazIbrahim M El-Sherbiny
Nov 9, 2016·International Journal of Pharmaceutics·Mazen M El-HammadiJosé L Arias
Nov 24, 2016·Journal of Biomaterials Science. Polymer Edition·D P BiswasA J O'Connor
Dec 6, 2017·Advanced Healthcare Materials·Nikhil PandeyYi Hong
Oct 30, 2013·Dalton Transactions : an International Journal of Inorganic Chemistry·Britta FischerBernhard K Keppler
Sep 7, 2019·Drug Development and Industrial Pharmacy·Behiye Şenel, A Alper Öztürk
Sep 26, 2019·Pharmaceutical Development and Technology·Seda RençberSinem Yaprak Karavana
Aug 20, 2017·Scientific Reports·Duong Q LeSuchismita Acharya
Mar 3, 2020·Frontiers in Bioengineering and Biotechnology·Divesha EssaViness Pillay
Apr 3, 2020·Environmental Science and Pollution Research International·Giorgio SpadolaDominga Rogolino
Oct 19, 2017·Scientific Reports·Jyothi U MenonKytai T Nguyen
Feb 6, 2021·International Journal of Pharmaceutics·Zachary R StrombergJennifer S Martinez
Jul 31, 2019·Molecular Pharmaceutics·Marline N'DiayeVéronique Rosilio
Nov 11, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Andrea GonsalvesJyothi U Menon

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.